{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:17:49Z","timestamp":1777853869912,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Cleveland Clinic Research Programs Committees","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Purpose: We sought to evaluate critically ill patients with delirium to evaluate inflammatory cytokine production and delirium progression and the role of antipsychotics. Materials and Methods: Adult critically ill patients with confirmed delirium according to a positive CAM-ICU score were included and IL-6 and IL-8 levels were trended for 24\u2005h in this single-center, prospective, observational cohort study. Results: A total of 23 patients were consented and had blood samples drawn for inclusion. There was no difference in IL-6 and IL-8 levels at baseline, 4 to 8\u2005h, and 22 to 28\u2005h after enrollment when comparing patients based on antipsychotic exposure. We identified 2 patient clusters based on age, APACHE III, need for mechanical ventilation, and concomitant infection. In cluster 1, 5 (33.3%) patients received antipsychotics versus 5 (62.5%) patients in cluster 2 ( P\u2009=\u2009.18). Patients in cluster 1 had more co-inflammatory conditions ( P\u2009&lt;\u2009.0001), yet numerically lower baseline IL-6 ( P\u2009=\u2009.18) and IL-8 levels ( P\u2009=\u2009.80) compared to cluster 2. Patients in cluster 1 had a greater median number of delirium-free days compared to cluster 2 (17.0 vs 6.0 days; P\u2009=\u2009.05). Conclusions: In critically ill patients with delirium, IL-6 and IL-8 levels were variable and antipsychotics were not associated with improvements in delirium or inflammatory markers.<\/jats:p>","DOI":"10.1177\/08850666231201567","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T03:19:01Z","timestamp":1695093541000},"page":"313-319","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Antipsychotic Use for ICU Delirium and Associated Inflammatory Markers"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1961-4104","authenticated-orcid":false,"given":"Heather","family":"Torbic","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mollie","family":"Lumpkin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4391-9645","authenticated-orcid":false,"given":"Jason","family":"Yerke","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Mehkri","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susamma","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijit","family":"Duggal","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Cleveland Clinic, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel G.","family":"Scheraga","sequence":"additional","affiliation":[{"name":"Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, USA"},{"name":"Department of Critical Care and Pulmonary Medicine, Cleveland Clinic, Cleveland, OH, 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