{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T19:06:17Z","timestamp":1788721577611,"version":"build-2803163510"},"reference-count":28,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Mechanical ventilation serves as crucial life support for critically ill patients. Although it is life-saving prolonged ventilation carries risks and complications like barotrauma, Ventilator-associated pneumonia, sepsis, and many others. Optimizing patient-ventilator interactions and facilitating early weaning is necessary for improved intensive care unit (ICU) outcomes. Traditionally Pressure support ventilation (PSV) mode is widely used for weaning patients who are intubated and mechanically ventilated. Neurally adjusted ventilatory assist (NAVA) mode of the ventilator is an emerging ventilator mode that delivers pressure depending on the patient's respiratory drive, which in turn prevents over-inflation and improves the patient's ventilator interactions. Our article revises and compares the effectiveness of NAVA compared to PSV ventilation under different contexts. Overall we conclude that NAVA level of ventilation can be safely administered in a patient with acute respiratory failure, provided diaphragmatic paralysis is not considered. NAVA improves asynchrony index, wean-off time, and sleep quality and is associated with increased ventilator-free days. These results are based on small-scale studies with low power, and further studies are warranted in large-scale cohorts with more diverse populations to confirm these results.<\/jats:p>","DOI":"10.1177\/08850666231212807","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T03:44:13Z","timestamp":1700019853000},"page":"1194-1203","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Neurally Adjusted Ventilatory Assist Versus Pressure Support Ventilation: A Comprehensive Review"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5252-4680","authenticated-orcid":false,"given":"Saikiran","family":"Mandyam","sequence":"first","affiliation":[{"name":"Internal Medicine Resident, Southeast Medical Center, Dothan, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Internal Medicine Resident, Southeast Medical Center, Dothan, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamini","family":"Katamreddy","sequence":"additional","affiliation":[{"name":"Internal Medicine Resident, West Anaheim Medical Center, Dothan, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devam","family":"Parghi","sequence":"additional","affiliation":[{"name":"Critical Care Medicine, Southeast Medical Center, Dothan, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Patel","sequence":"additional","affiliation":[{"name":"Internal Medicine Resident, Southeast Medical Center, Dothan, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhi","family":"Patel","sequence":"additional","affiliation":[{"name":"Internal Medicine Resident, Southeast Medical Center, Dothan, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fnu","family":"Anshul","sequence":"additional","affiliation":[{"name":"Critical Care Medicine, Southeast Medical Center, Dothan, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"bibr1-08850666231212807","unstructured":"Hyzy RC. https:\/\/www.uptodate.com\/contents\/clinical-and-physiologic-complications-of-mechanical-ventilation-overview."},{"key":"bibr2-08850666231212807","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.6.2146"},{"key":"bibr3-08850666231212807","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1977.116.3.449"},{"key":"bibr4-08850666231212807","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.5.2092"},{"key":"bibr5-08850666231212807","first-page":"2013","volume":"35","author":"Petit JM","year":"1959","journal-title":"Boll Soc Ital Biol Sper"},{"key":"bibr6-08850666231212807","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1587-0"},{"key":"bibr7-08850666231212807","doi-asserted-by":"publisher","DOI":"10.1186\/cc12865"},{"key":"bibr8-08850666231212807","unstructured":"Shah SD, Anjum F. Neurally adjusted ventilatory assist (NAVA) [Updated 2022 Jun 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan- https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK572111\/"},{"key":"bibr9-08850666231212807","first-page":"1863","volume":"11","author":"Umbrello M","year":"2022","journal-title":"Clin Med"},{"key":"bibr10-08850666231212807","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1178-0"},{"key":"bibr11-08850666231212807","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201502-0346UP"},{"key":"bibr12-08850666231212807","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2172-0"},{"key":"bibr13-08850666231212807","unstructured":"Diniz-Silva F, Moriya HT, Alencar AM, Amato MBP, Carvalho CRR, Ferreira JC. Neurally adjusted ventilatory assist vs. pressure support to deliver protective mechanical ventilation in patients with acute respiratory distress syndrome: a randomised crossover trial."},{"key":"bibr14-08850666231212807","unstructured":"Liu L, Xu X, Sun Q, et al. Neurally Adjusted Ventilatory Assist versus Pressure Support Ventilation in Difficult Weaning: A Randomized Trial."},{"key":"bibr15-08850666231212807","unstructured":"Demoule A, Clavel M, Rolland-Debord C, et al. Neurally adjusted ventilatory assist as an alternative to pressure support ventilation in adults: a French multicentre randomized trial."},{"key":"bibr16-08850666231212807","unstructured":"Barwing J, Linden N, Ambold M, Quintel M, Moerer O. Neurally adjusted ventilatory assist vs. pressure support ventilation in critically ill patients: an observational study."},{"key":"bibr17-08850666231212807","unstructured":"Cammarota G, Verdina F, De Vita N, et al. Effects of Varying Levels of Inspiratory Assistance with Pressure Support Ventilation and Neurally Adjusted Ventilatory Assist on Driving Pressure in Patients Recovering from Hypoxemic Respiratory Failure."},{"key":"bibr18-08850666231212807","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1410639"},{"key":"bibr19-08850666231212807","unstructured":"Ferreira JC, Diniz-Silva F, Moriya HT, Alencar AM, Amato MBP, Carvalho CRR. Neurally Adjusted Ventilatory Assist (NAVA) or Pressure Support Ventilation (PSV) during spontaneous breathing trials in critically ill patients: a crossover trial."},{"key":"bibr20-08850666231212807","unstructured":"Lamouret O, Crognier L, Bounes FV, et al. Neurally adjusted ventilatory assist (NAVA) versus pressure support ventilation: patient-ventilator interaction during invasive ventilation delivered by tracheostomy."},{"key":"bibr21-08850666231212807","unstructured":"Yonis H, Crognier L, Conil J-M, et al. Patient-ventilator synchrony in Neurally Adjusted Ventilatory Assist (NAVA) and Pressure Support Ventilation (PSV): a prospective observational study."},{"key":"bibr22-08850666231212807","unstructured":"Delisle S, Ouellet P, Bellemare P, T\u00e9trault J-P, Arsenault P. Sleep quality in mechanically ventilated patients: comparison between NAVA and PSV modes."},{"key":"bibr23-08850666231212807","unstructured":"Jalde FC, Jalde F, Wallin MKEB, et al. Standardized Unloading of Respiratory Muscles during Neurally Adjusted Ventilatory Assist: A Randomized Crossover Pilot Study."},{"key":"bibr24-08850666231212807","unstructured":"Xu XT, Sun Q, Xie JF, et al. Effect of neurally adjusted ventilatory assist on trigger of mechanical ventilation in acute exacerbation of chronic obstructive pulmonary disease patients with intrinsic positive end-expiratory pressure."},{"key":"bibr25-08850666231212807","unstructured":"Roz\u00e9 H, Repusseau B, Perrier V, et al. Neuro-ventilatory efficiency during weaning from mechanical ventilation using neurally adjusted ventilatory assist."},{"key":"bibr26-08850666231212807","unstructured":"Kuo N-Y, Tu M-L, Hung T-Y, et al. 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