{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:55:54Z","timestamp":1791939354174,"version":"4.3.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is implicated in the development of gastritis, ulcers, and various gastric cancers, representing significant morbidity, mortality, and healthcare spending. Patients with\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection have traditionally been treated with oral antibiotics, however, oral therapy is not feasible in all clinical situations. We examined the available evidence supporting the use of intravenous (IV) antibiotics in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    .\n                    <jats:bold>Methods:<\/jats:bold>\n                    This systematic review was carried out by reviewing multiple electronic databases: MEDLINE, CENTRAL, EMBASE, CINAHL, Clinicaltrials.org, and the World Health Organization (WHO) database of clinical trials. Articles published from database inception until February 12, 2023 that discussed the use of IV antibiotics in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    management were included.\n                    <jats:bold>Results:<\/jats:bold>\n                    The search strategy identified 978 studies, with 11 meeting the inclusion criteria. The results demonstrate that there is a lack of robust trials examining the use of IV antibiotics in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    management. Many trials demonstrated that IV antibiotics were safe and efficacious but the results are limited by inconsistencies in the year and geographic location trials were conducted, the IV and oral antibiotic regimens, and the duration of therapy.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    IV antibiotics appear to be a feasible therapeutic alternative in the management of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    and can be considered, especially in patient populations where oral therapy is contraindicated.\n                  <\/jats:p>","DOI":"10.1177\/08850666241245364","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T05:25:40Z","timestamp":1712813140000},"page":"818-828","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Intravenous Antibiotics in the Management of\n                    <i>H. pylori<\/i>\n                    Infection: A Systematic Review"],"prefix":"10.1177","volume":"40","author":[{"given":"Yau-Lam Alex","family":"Chau","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Vancouver General Hospital, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Milic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Vancouver General Hospital, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4341-1278","authenticated-orcid":false,"given":"Jerrold","family":"Perrott","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Vancouver General Hospital, Vancouver, BC, Canada"},{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.10.4.720"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a018040"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613042"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-017-1256-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08504-5"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2022.2056015"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.006"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001719"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002546"},{"key":"e_1_3_2_12_2","unstructured":"Covidence. 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A three-day course of intravenous omeprazole plus antibiotics for H. pylori-positive bleeding duodenal ulcer. Hetaptogastroenterology. 1999;46(28):2363-2371.","journal-title":"Hetaptogastroenterology"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01763.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12946"},{"issue":"11","key":"e_1_3_2_18_2","first-page":"1980","article-title":"Combined intravenous and oral omeprazole\/amoxicillin therapy in patients with Helicobacter pylori-positive acute peptic ulcer bleeding","volume":"88","author":"Adamek RJ","year":"1993","unstructured":"Adamek RJ, Wegener M. Combined intravenous and oral omeprazole\/amoxicillin therapy in patients with Helicobacter pylori-positive acute peptic ulcer bleeding. 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