{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:18:14Z","timestamp":1777853894104,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Purpose: The purpose of this study was to evaluate rates of delirium or coma-free days between continuous infusion sedative-dose ketamine and continuous infusion benzodiazepines in critically ill patients. Materials and Methods: In this single-center, retrospective cohort adult patients were screened for inclusion if they received continuous infusions of either sedative-dose ketamine or benzodiazepines (lorazepam or midazolam) for at least 24\u2005h, were mechanically ventilated for at least 48\u2005h and admitted to the intensive care unit of a large quaternary academic center between 5\/5\/2018 and 12\/1\/2021. Results: A total of 165 patients were included with 64 patients in the ketamine group and 101 patients in the benzodiazepine group (lorazepam n\u2009=\u200935, midazolam n\u2009=\u200978). The primary outcome of median (IQR) delirium or coma-free days within the first 28 days of hospitalization was 1.2 (0.0, 3.7) for ketamine and 1.8 (0.7, 4.6) for benzodiazepines (p\u2009=\u20090.13). Patients in the ketamine arm spent a significantly lower proportion of time with RASS \u22123 to +4, received significantly higher doses and longer durations of propofol and fentanyl infusions, and had a significantly longer intensive care unit length of stay. Conclusions: The use of sedative-dose ketamine had no difference in delirium or coma-free days compared to benzodiazepines.<\/jats:p>","DOI":"10.1177\/08850666241253541","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T02:27:29Z","timestamp":1716431249000},"page":"1204-1211","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Continuous Infusion Ketamine Compared to Continuous Infusion Benzodiazepines on Delirium in the Intensive Care Unit"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-3811","authenticated-orcid":false,"given":"Nicholas J.","family":"Vollmer","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Mayo Clinic Hospital, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7703-2233","authenticated-orcid":false,"given":"Erin D.","family":"Wieruszewski","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mayo Clinic Hospital, Rochester, MN, USA"},{"name":"Department of Emergency Medicine, Mayo Clinic Hospital, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6533-5843","authenticated-orcid":false,"given":"Andrea M.","family":"Nei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mayo Clinic Hospital, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin C.","family":"Mara","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic Hospital, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro A.","family":"Rabinstein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic Hospital, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin S.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Mayo Clinic Hospital, Rochester, MN, USA"},{"name":"Department of Emergency Medicine, Mayo Clinic Hospital, Rochester, MN, 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