{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:39:02Z","timestamp":1790707142838,"version":"4.1.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intensive care unit acquired weakness (ICUAW) is a common neuromuscular complication of critical illness, impacting patients\u2019 recovery and long-term outcomes. However, limited evidence is available on pooled prevalence and risk factors of ICUAW specifically in the COVID-19-infected population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched on PubMed, Embase, Cochrane Library, Web of Science, PEDro, and EBSCOhost\/CINAHL up to January 31, 2024. Data synthesis was conducted using the Freeman-Tukey double-arcsine transformation model for the pooled prevalence rate and odds ratios with corresponding 95% confidence intervals was used to identify risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The pooled prevalence of ICUAW in COVID-19 patients was 55% in eight studies on 868 patients. Risk factors for developing ICUAW in these patients were: old age (WMD 4.78, 95% CI, 1.06-8.49), pre-existing hypertension (OR\u2009=\u20091.63, 95% CI, 1.02-2.61), medical intervention of prone position (OR\u2009=\u20095.21, 95% CI, 2.72-9.98), use of neuromuscular blocking agents (NMBA) (OR\u2009=\u200912.04, 95% CI, 6.20-23.39), needed tracheostomy (OR\u2009=\u200918.07, 95% CI, 5.64-57.92) and renal replacement therapy (RRT) (OR\u2009=\u20095.24, 95% CI\u2009=\u20092.36-11.63).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of ICUAW in patients with COVID-19 was considered relatively high. Older age, pre-existing hypertension, medical intervention of prone position, NMBA use, needed tracheostomy and RRT were likely risk factors. In the future, interdisciplinary medical team should pay attention to high-risk groups for ICUAW prevention and early treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666241268437","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T07:11:45Z","timestamp":1723619505000},"page":"1042-1051","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and Risk Factors of Intensive Care Unit-acquired Weakness in Patients With COVID-19: A Systematic Review and Meta-analysis"],"prefix":"10.1177","volume":"40","author":[{"given":"Ya-Chi","family":"Chuang","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sz-Iuan","family":"Shiu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC"},{"name":"Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC"},{"name":"Evidence-Based Practice and Policymaking Committee, Taichung Veterans General Hospital, Taichung, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung, Taiwan, ROC"},{"name":"Department of Exercise Health Science, National Taiwan University of Sport, Taichung, Taiwan, ROC"},{"name":"Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5267-6681","authenticated-orcid":false,"given":"Yu-Lin","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung, Taiwan, ROC"},{"name":"Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung, Taiwan, ROC"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"512","article-title":"COVID-19 and ICU admission associated predictive factors in Iranian patients. 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