{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:18:34Z","timestamp":1777853914189,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Takotsubo Cardiomyopathy (TCM) is a rare but well recognized complication of subarachnoid hemorrhage associated with increased morbidity and poor clinical outcomes. There is a scarcity of literature describing the prevalence and risk factors associated with this complication. The aim of this study was to identify patients who are at risk of developing TCM in non-traumatic subarachnoid hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The 2016 to 2021 National Inpatient Sample (NIS) was used to identify adult inpatients with a primary diagnosis of non-traumatic subarachnoid hemorrhage. Univariate and multivariable analyses adjusting for patient demographics, comorbidity status, and hemorrhage etiology were used to characterize statistical associations with disease-related complications. Patients with TCM were further divided into those with \u201cgood\u201d or \u201cpoor\u201d functional outcomes and compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 42\u2005141 patients were identified as having a subarachnoid hemorrhage from 2016 to 2021. Of these patients 486 patients (1.2%) were found to have TCM. TCM was associated with increased length of stay (19.15\u2009\u00b1\u200917.8 days vs 11.72\u2009\u00b1\u200914.4,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), increased total costs ($451\u2005502.59\u2009\u00b1\u2009443\u2005777.9 vs $242\u2005327.92\u2009\u00b1\u2009338\u2005862.3,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), increased number of days from admission to first procedure (1.74\u2009\u00b1\u20094.5 vs 1.94\u2009\u00b1\u20095.0,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and increased mortality (31.7% vs 22.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). After controlling for confounding factors, independent risk factors for TCM in patients with non-traumatic subarachnoid hemorrhage included: Female (Odds Ratio [OR]: 3.11, 95% Confidence Interval [CI]: 2.50-3.89,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), Congestive Heart Failure (OR:4.60, CI:3.70-5.71,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and Fluid and Electrolyte Disorders (OR: 2.52, CI: 2.05-3.11,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Patients with good functional outcomes were found to have younger age (54.85 years\u2009\u00b1\u200914.0 vs 58.14\u2009\u00b1\u200914.7,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), decreased length of stay (17.11\u2009\u00b1\u200916.9 vs 19.83\u2009\u00b1\u200918.1,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), decreased total charge ($370\u2005245.94\u2009\u00b1\u2009517\u2005702.8 vs $477\u2005366.55\u2009\u00b1\u2009417\u2005122.4,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and decreased mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) compared to those with poor functional outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TCM after subarachnoid hemorrhage is associated with increased mortality, length of stay, total cost, number of procedures in patients, and number of days to first procedure. Neurosurgeons and Neurocritical care medical professionals should be aware of the comorbidities and factors associated with increased TCM after subarachnoid hemorrhage in order to improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666251313759","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:25:18Z","timestamp":1737332718000},"page":"749-758","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Takotsubo Cardiomyopathy After Subarachnoid Hemorrhage: Who Is At Risk?"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-4889","authenticated-orcid":false,"given":"Alejandro","family":"Pando","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Rutgers New Jersey Medical School, Rutgers Robert Wood Johnson Medical School, Newark, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caryn J.","family":"Ha","sequence":"additional","affiliation":[{"name":"Rutgers New Jersey Medical School, Newark, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2642-7590","authenticated-orcid":false,"given":"Arevik","family":"Abramyan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sourav","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"USDA Forest Service Center for Forested Wetlands Research, Cordesville, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey Pradeep","family":"Raj","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Pharmacology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, KA, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K.","family":"Liu","sequence":"additional","affiliation":[{"name":"Neurosurgeons of New Jersey, NYU Langone Neurosurgery Network, Department of Neurosurgery, Cooperman Barnabas Medical Center, RWJ Barnabas Health, Livingston, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chief of Intensive Neurocritical Care, Morristown Medical Center and Atlantic Health System New Jersey, Morristown, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-019-01096-2"},{"key":"e_1_3_2_3_2","unstructured":"Ziu E Khan Suheb MZ Mesfin FB. 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