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In the time since the COVID 19 pandemic gripped our medical systems, we can now explore the data that has been collected from the previous years. The literature has allowed us to better understand the impact of COVID 19 and the post illness occurrence of a severe systemic inflammatory disease on our youngest patient populations. This paper will outline the pathophysiology of MIS-C, the treatments utilized, short and long-term patient outcomes including epidemiological factors.<\/jats:p>","DOI":"10.1177\/08850666251320558","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T13:29:12Z","timestamp":1742218152000},"page":"284-308","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Multisystem Inflammatory Syndrome in Children: A Comprehensive Review Over the Past Five Years"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4168-8354","authenticated-orcid":false,"given":"Olivia","family":"Shyong","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Alfakhri","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara V.","family":"Bates","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan W.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6881-6423","authenticated-orcid":false,"given":"Krista","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Huang","sequence":"additional","affiliation":[{"name":"Touro University Nevada, College of Osteopathic Medicine, Henderson, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia A.","family":"Okrzesik","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe H.","family":"Yager","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lael M.","family":"Yonker","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA, USA"},{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Lok","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"},{"name":"Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12969-021-00511-7","article-title":"Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: results from a national, multicenter survey","volume":"19","author":"Cattalini M","unstructured":"Cattalini M, Della Paolera S, Zunica F, et al. 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