{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:24:06Z","timestamp":1779377046526,"version":"3.53.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Nephrotoxicity remains a significant concern in the management of critically ill patients receiving antibiotic therapy. The combination of Vancomycin and Piperacillin-Tazobactam (VPT) is frequently employed to combat multidrug-resistant infections. However, emerging evidence suggests a potential increase in the risk of acute kidney injury (AKI) associated with this combination. This study aims to systematically review and analyze the nephrotoxic risk of the VPT combination in comparison to Vancomycin with Cefepime (VC) combination therapy.\n                    <jats:bold>Methodology:<\/jats:bold>\n                    We conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was performed in databases including PubMed and Google Scholar for studies published until 2024. Studies that reported AKI incidence in patients treated with VPT, or VC were included. The data were analyzed using random-effects models to estimate pooled incidence rates of AKI. Subgroup analyses were performed based on patient demographics and baseline renal function.\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of six studies involving 23\u2005794 patients were included in the analysis. The pooled incidence of AKI in the VPT group was found to be 29.9% (95% CI: 25.3%-38.4%), significantly higher than that of the VC (22.7%) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). A comparative analysis demonstrated a significantly higher risk of AKI in patients on VPT compared to VC (1.503; 95% CI: 1.221-1.849\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The findings of this study underscore a significant increase in the risk of AKI associated with the Vancomycin and Piperacillin-Tazobactam combination in critically ill patients. Clinicians should exercise caution when prescribing this combination, particularly for patients with pre-existing renal dysfunction.\n                  <\/jats:p>","DOI":"10.1177\/08850666251323265","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T02:23:47Z","timestamp":1742783027000},"page":"447-455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Incidence of Acute Kidney Injury (AKI) in Critically Ill Patients Receiving Concomitant Vancomycin with Piperacillin-Tazobactam or Cefepime; a Systemic Review and Meta-analysis"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8020-5755","authenticated-orcid":false,"given":"Lamees","family":"Alaradi","sequence":"first","affiliation":[{"name":"College of Medicine, Princess Nourah bint Abdulrahman University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0146-5334","authenticated-orcid":false,"given":"Nada","family":"Albariqi","sequence":"additional","affiliation":[{"name":"Ibn Sina National College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8054-3485","authenticated-orcid":false,"given":"Mona","family":"Alanazi","sequence":"additional","affiliation":[{"name":"University of Tabuk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3437-1623","authenticated-orcid":false,"given":"Naif","family":"Alghassab","sequence":"additional","affiliation":[{"name":"Imam Mohammed Ibn Saud Islamic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6459-4328","authenticated-orcid":false,"given":"Tief","family":"Aseri","sequence":"additional","affiliation":[{"name":"Taif University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1301-8842","authenticated-orcid":false,"given":"Lujain","family":"Alahmadi","sequence":"additional","affiliation":[{"name":"Ibn Sina National College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0550-7515","authenticated-orcid":false,"given":"Ahmad","family":"Alahmadi","sequence":"additional","affiliation":[{"name":"Umm Al-Qura University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseel","family":"Althobaiti","sequence":"additional","affiliation":[{"name":"Taif University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5186-3201","authenticated-orcid":false,"given":"Yousef","family":"Alqarafi","sequence":"additional","affiliation":[{"name":"College of Medicine, Hail University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5606-7742","authenticated-orcid":false,"given":"Habeeba","family":"Bokhari","sequence":"additional","affiliation":[{"name":"Taif University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayan A","family":"Qutob","sequence":"additional","affiliation":[{"name":"Imam Mohammad Ibn Saud Islamic University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohanad","family":"Almaimani","sequence":"additional","affiliation":[{"name":"University of Jeddah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"issue":"2","key":"e_1_3_2_2_2","first-page":"85","article-title":"Acute kidney injury: Definition, pathophysiology and clinical phenotypes","volume":"37","author":"Makris K","year":"2016","unstructured":"Makris K, Spanou L. Acute kidney injury: Definition, pathophysiology and clinical phenotypes. Clin Biochem Rev. 2016;37(2):85\u201398.","journal-title":"Clin Biochem Rev"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010375"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.12788\/jhm.2684"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1738"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066619828290"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneph.2022.995358"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy724"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.03.046"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02658-18"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-022-06811-0"},{"issue":"8","key":"e_1_3_2_12_2","article-title":"Piperacillin-tazobactam plus vancomycin-associated acute kidney injury in adults: Can teicoplanin or other antipseudomonal beta-lactams be remedies?","volume":"10","author":"Aslan AT","year":"2022","unstructured":"Aslan AT, Akova M. Piperacillin-tazobactam plus vancomycin-associated acute kidney injury in adults: Can teicoplanin or other antipseudomonal beta-lactams be remedies? Healthcare (Basel). 2022;10(8). doi:https:\/\/doi.org\/10.3390\/healthcare10081582.","journal-title":"Healthcare (Basel)"},{"issue":"2","key":"e_1_3_2_13_2","article-title":"Considerations for empiric antimicrobial therapy in sepsis and septic shock in an era of antimicrobial resistance","volume":"222","author":"Strich JR","year":"2020","unstructured":"Strich JR, Heil EL, Masur H. Considerations for empiric antimicrobial therapy in sepsis and septic shock in an era of antimicrobial resistance. J Infect Dis. 2020;222(Suppl 2):S119\u2013S131. doi:https:\/\/doi.org\/10.1093\/infdis\/jiaa221","journal-title":"J Infect Dis"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05041-11"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13092455"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-017-0260-y"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106010"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.03.024"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042018816638223"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix675"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.08.031"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3446-x"},{"issue":"7","key":"e_1_3_2_23_2","article-title":"Mechanisms of piperacillin\/tazobactam nephrotoxicity: Piperacillin\/tazobactam-induced direct tubular damage in mice","volume":"12","author":"Yang J","year":"2023","unstructured":"Yang J, Ko YS, Lee HY, et al. Mechanisms of piperacillin\/tazobactam nephrotoxicity: Piperacillin\/tazobactam-induced direct tubular damage in mice. Antibiotics (Basel). 2023;12(7). doi:https:\/\/doi.org\/10.3390\/antibiotics12071121.","journal-title":"Antibiotics (Basel)"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/20499361231189589"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00432-2"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0008112021"},{"issue":"10","key":"e_1_3_2_27_2","article-title":"The risk and clinical implications of antibiotic-associated acute kidney injury: A review of the clinical data for agents with signals from the food and drug administration\u2019s adverse event reporting system (FAERS) database","volume":"11","author":"Clifford KM","year":"2022","unstructured":"Clifford KM, Selby AR, Reveles KR, et al. The risk and clinical implications of antibiotic-associated acute kidney injury: A review of the clinical data for agents with signals from the food and drug administration\u2019s adverse event reporting system (FAERS) database. 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