{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:09:27Z","timestamp":1793916567966,"version":"4.8.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hemoadsorption is currently employed to treat septic shock and other clinical conditions involving massive inflammatory mediator release. CytoSorb\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , a device utilizing synthetic resin microbeads, provides a large adsorption surface for blood purification. This study aimed to review the clinical course of patients with septic shock treated with CytoSorb\n                      <jats:sup>\u00ae<\/jats:sup>\n                      in our hospital's intensive care unit (ICU).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      This study retrospectively analyzed the clinical course of patients with septic shock treated with CytoSorb\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , focusing on treatment timing and the volume of blood processed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between July 1, 2016, and December 31, 2023, 175 patients (106 men, 69 women; median age: 67 years, interquartile [IQR]: 58-85) received CytoSorb\n                      <jats:sup>\u00ae<\/jats:sup>\n                      therapy. Survivors exhibited a significantly lower simplified acute physiology score at admission than nonsurvivors. CytoSorb\n                      <jats:sup>\u00ae<\/jats:sup>\n                      was initiated within 24 h of shock onset in 102 patients (58%, early starters) and between 25 and 48 h in 73 patients (42%, late starters). Hemodynamic improvements elevated mean arterial pressure and reduced lactate, procalcitonin, C-reactive protein, sequential organ failure assessment scores, and noradrenaline doses in survivors. These effects were more pronounced in early starters receiving intensive treatment, who also demonstrated significantly lower lactate levels and higher mean arterial pressure at the end of therapy. Overall, 86 patients (49%) died in the ICU. Survivors underwent longer treatment durations and processed greater blood volumes than nonsurvivors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In patients with septic shock treated with CytoSorb\n                      <jats:sup>\u00ae<\/jats:sup>\n                      within 48\u2005h of onset, treatment intensity\u2013rather than timing\u2013was associated with lower ICU mortality rates.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666251331905","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T04:21:47Z","timestamp":1743567707000},"page":"993-1000","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Real-World Outcomes of Hemoadsorption with CytoSorb\n                    <sup>\u00ae<\/sup>\n                    in Patients with Septic Shock: Insights from a Single-Center Study"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-4283","authenticated-orcid":false,"given":"Giorgio","family":"Berlot","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Intensive Care and Pain Therapy, Cattinara Hospital, Azienda Sanitaria Universitaria Giuliano-Isontina, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Carocci","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Intensive Care and Pain Therapy, Cattinara Hospital, Azienda Sanitaria Universitaria Giuliano-Isontina, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Votrico","sequence":"additional","affiliation":[{"name":"Department Of Nephrology, Pordenone Hospital, Azienda Sanitaria Friuli Orientale, Pordenone, 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