{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:18:48Z","timestamp":1777853928176,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Vasoplegic syndrome is a complication that may occur during liver transplantation, most often after donor graft reperfusion. Multiple factors in end-stage liver disease (ESLD) may contribute to this vasodilation which may be exacerbated during reperfusion in liver transplantation. Two cases of vasoplegia during living donor liver transplantation are reported along with a systematic review of current literature. These patients were successfully treated with methylene blue and cyanocobalamin. All publications between January 1992 to september 2024 that assessed the use of methylene blue and\/or cyanocobalamin in vasoplegia during liver transplantation in humans were included. Seven case reports and one case series were found and reviewed. These consisted of 4 case reports of vasoplegic syndrome during liver transplantation treated with methylene blue and other four describing the use of cyanocobalamin. A total of twenty-four patients were treated with methylene blue and eight patients with cyanocobalamin in the reviewed articles and all patients had a beneficial impact on blood pressure after administration of the medications. Patients affected by vasoplegia during liver transplantation show encouraging results when treated with methylene blue and cyanocobalamin, but these data have to be confirmed by additional studies.<\/jats:p>","DOI":"10.1177\/08850666251347951","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T21:38:48Z","timestamp":1749159528000},"page":"907-914","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Methylene Blue and Cyanocobalamin for Vasoplegic Syndrome in Liver Transplantation"],"prefix":"10.1177","volume":"40","author":[{"given":"Yaroslava","family":"Longhitano","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Perioperative Medicine, University of Pittsburgh Medical Centre, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezeldeen","family":"Albuelkasem","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Perioperative Medicine, University of Pittsburgh Medical Centre, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Voza","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, IRCCS-Humanitas Research Hospital, Rozzano, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-7554","authenticated-orcid":false,"given":"Luigi","family":"La Via","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, University Hospital Policlinico-San Marco, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-6118","authenticated-orcid":false,"given":"Christian","family":"Zanza","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine - Geriatric Medicine Residency Program, University of Rome \"Tor Vergata\", Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond M.","family":"Planinsic","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Perioperative Medicine, University of Pittsburgh Medical Centre, Pittsburgh, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2017.04.017"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2010.09.018"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2022.107488"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.15271"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2016.10.011"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14736"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2020.09.019"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181a286fc"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2008.07.015"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2011.10.010"},{"key":"e_1_3_3_12_2","first-page":"6610754","article-title":"The use of methylene blue during liver transplantation for vasoplegia","volume":"2021","author":"Harding P","year":"2021","unstructured":"Harding P, Nicholas T, Kassel C. The use of methylene blue during liver transplantation for vasoplegia. Case Rep Anesthesiol. 2021;2021:6610754. PMID: 34258070; PMCID: PMC8245233. doi:https:\/\/doi.org\/10.1155\/2021\/6610754","journal-title":"Case Rep Anesthesiol"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-017-0789-6"},{"issue":"2","key":"e_1_3_3_14_2","article-title":"The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule","volume":"43","author":"Iwakiri Y","year":"2006","unstructured":"Iwakiri Y, Groszmann RJ. The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule. 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