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Our objective is to identify how many patients previously identified as having severe sepsis would continue to meet the new definition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We performed a secondary analysis of the Phenotyping Sepsis-Induced Multiple Organ Failure cohort of 401 children with suspected or confirmed infection, two of four SIRS criteria and organ dysfunction enrolled between 2015-2017. We calculated a modified Phoenix Sepsis Criteria Score (mPSC) for participants and compared those with mPSC of greater than or equal to 2 or less than 2 according to the 2024 definition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 401 children, 132 (33%) did not meet mPSC definitions. While children meeting mPSC had more organ dysfunction, the total mortality did not differ. One in 4 children requiring extracorporeal membrane oxygenation and 1 in 4 mortalities did not meet the mPSC definition. In logistic regression models, in the complete cohort, hematologic (OR 4.4, 95% CI: 1.8-10.2,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -value\u2009=\u2009.001), central nervous system (OR 2.3, 95% CI: 1.0-5.1,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -value\u2009=\u2009.046) and renal failure (OR: 3.2, 95% CI:1.2-7.9,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -value\u2009=\u2009.017) predicted mortality; in the mPSC subgroup pulmonary (OR: 3.6, 95% CI:1.3-13.3,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -value\u2009=\u2009.030) and hematologic failure (OR 5.6, 95% CI: 2.2-14.5,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -value\u2009=\u2009.0003) were significant predictors. In the mPSC excluded subgroup, only renal failure predicted mortality (OR 9.6, 95% CI 1.1-73.0,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      -value\u2009=\u2009.028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Further study of the impact of the 2024 data-driven organ dysfunction definition on pediatric sepsis research, patient safety, and clinical benchmarking efforts is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666251349790","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T04:15:28Z","timestamp":1750047328000},"page":"1260-1268","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Application of New Pediatric Sepsis Definition to a Multicenter Observational Cohort of Previously Enrolled Severe Sepsis Patients Defined by SIRS Plus Organ Dysfunction"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6337-841X","authenticated-orcid":false,"given":"Kate F.","family":"Kernan","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Shaik","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Horvat","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana Y.","family":"Fuhrman","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4367-9036","authenticated-orcid":false,"given":"Zachary","family":"Aldewereld","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wessel","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, Children's National Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray M.","family":"Pollack","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, Children's National Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Meert","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI, USA"},{"name":"Department of Pediatrics, Central Michigan University, Mt. 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