{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:05:04Z","timestamp":1780538704194,"version":"3.54.1"},"reference-count":9,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extracorporeal Membrane Oxygenation (ECMO) is a critical support system for patients with acute and severe cardiac and respiratory failure. This study investigates the impact of different patient body weight categories on the mortality rates of patients undergoing ECMO support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Nationwide Sample (NIS) database and ICD-10 codes for 2016 to 2020 in adults over age 18, we evaluated total mortality based on weight categories compared to normal weights using univariate and multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total population of 47\u2005990 patients underwent ECMO insertion with a mean age of 52.6 years. Total mortality was 45.7%. Patients with cachexia, overweight, and obesity had similar mortality to normal-weight patients. (Cachexia: 43.75%, normal weight: 46.30%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.60, OR\u2009=\u20090.90, 95% CI: 0.61-1.33, overweight 42.31%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.69, OR\u2009=\u20090.85, 95% CI: 0.38-1.89, and obesity 45.73%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.73, OR\u2009=\u20090.98, 95% CI: 0.85-1.12). However, morbid obesity had the lowest mortality in the univariate analysis (41.89%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.01, OR\u2009=\u20090.84, 95% CI: 0.73-0.96) but was not significant in the multivariate analysis (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.66, OR: 0.97, CI: 0.83-1.12). Separating peripheral veno-arterial versus veno-venous ECMO showed similar results with similar mortalities based on weight categories.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest that the \u2018obesity paradox\u2019 does not exist in ECMO-treated patients, with no effect of weight on total mortality . Further research is necessary to understand the underlying factors contributing to these outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666251351574","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T23:00:21Z","timestamp":1751065221000},"page":"1279-1284","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Weight Categories Have no Impact on Mortality in Patients Treated with Extracorporeal Membrane Oxygenation (ECMO)"],"prefix":"10.1177","volume":"40","author":[{"given":"Meredith","family":"Marefat","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Arizona Sarver Heart Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrtash","family":"Hashemzadeh","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Arizona, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7492-0510","authenticated-orcid":false,"given":"Mohammad Reza","family":"Movahed","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Arizona Sarver Heart Center"},{"name":"Department of Medicine, University of Arizona, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13195897"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3542"},{"key":"e_1_3_2_4_2","article-title":"Association of BMI with adherence and outcome in heart failure patients treated with wearable cardioverter defibrillator","author":"Abumayyaleh M","year":"2024","unstructured":"Abumayyaleh M, Koepsel K, Erath JW, et al. Association of BMI with adherence and outcome in heart failure patients treated with wearable cardioverter defibrillator. ESC Heart Fail. 2024. doi: https:\/\/doi.org\/10.1002\/ehf2.15141. Epub ahead of print. PMID: 39474928.","journal-title":"ESC Heart Fail"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2010.06.004"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2022.03.014"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202212-2293OC"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-022-06926-4"},{"key":"e_1_3_2_9_2","first-page":"9967357","article-title":"Obesity as a risk factor for failure to wean from ECMO: A systematic review and meta-analysis","volume":"2021","author":"Zaidi SAA","year":"2021","unstructured":"Zaidi SAA, Saleem K. Obesity as a risk factor for failure to wean from ECMO: A systematic review and meta-analysis. Can Respir J. 2021;2021:9967357, 8 pages. https:\/\/doi.org\/10.1155\/2021\/9967357","journal-title":"Can Respir J."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2023.10.025"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666251351574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08850666251351574","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666251351574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:58:32Z","timestamp":1777503512000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08850666251351574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/08850666251351574"],"URL":"https:\/\/doi.org\/10.1177\/08850666251351574","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,27]]}}}