{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:18:52Z","timestamp":1777853932585,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>An elevated ventilatory ratio (VR) and acute cor pulmonale (ACP) are associated with mortality in ARDS patients. The primary aim of this study was to assess the association between VR and ACP in patients with COVID-19-related ARDS (C-ARDS). The secondary objectives were to analyze the association between VR and ICU mortality, describe VR temporal behavior in survivors and non-survivors, and evaluate the association between VR and pulmonary embolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We studied a cohort of patients with C-ARDS. The VR was calculated using a validated formula. Echocardiography was used to diagnose ACP, and CT pulmonary angiography was performed to identify PE. To evaluate the associations between VR and ACP, mortality, and PE, a generalized logistic regression model was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 140 subjects, 60 (43%) had a VR\u2009&lt;\u20092, while 80 (57%) had a VR\u2009\u2265\u20092. Patients with a VR \u22652 had a higher risk of developing ACP than those with a VR &lt;2 (Odds Ratio (OR), 3.77; 95% CI: 1.30 - 8.72). The ICU mortality rate was 29%. Of the 40 patients who died, 30 (75%) had a VR\u2009\u2265\u20092. Mortality was significantly associated with VR\u2009\u2265\u20092 and driving pressure\u2009\u2265\u200915 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O. In non-survivor patients with a VR\u2009&lt;\u20092 at ICU admission, a significant increase in VR was observed over the 7-day observation period. No significant association was observed between PE and VR (p\u2009=\u2009.118).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Elevated VR was associated with ACP in patients with C-ARDS. VR\u2009\u2265\u20092 combined with driving pressure\u2009\u2265\u200915 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O significantly improved the ability to identify patients at risk for ACP. Additionally, at ICU admission, elevated VR values and initially low values that increased over the first week were associated with higher ICU mortality.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666251359548","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T14:59:21Z","timestamp":1757343561000},"page":"76-85","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Ventilatory Ratio with Acute Cor Pulmonale and Mortality in COVID-19 ARDS: A Cohort Study"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6366-534X","authenticated-orcid":false,"given":"Mart\u00edn H.","family":"Benites","sequence":"first","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica de Chile"},{"name":"Facultad de Medicina, Escuela de Medicina, Universidad Finis Terrae, Santiago, Chile"},{"name":"Unidad de Pacientes Cr\u00edticos, Cl\u00ednica Las Condes, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5947-6857","authenticated-orcid":false,"given":"Romina","family":"Battiato","sequence":"additional","affiliation":[{"name":"Mag\u00edster en Bioestad\u00edstica. 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Universidad de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Mercado","sequence":"additional","affiliation":[{"name":"Departamento de Paciente Cr\u00edtico, Cl\u00ednica Alemana de Santiago, Facultad de Medicina Cl\u00ednica Alemana - Universidad del Desarrollo, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Pairumani","sequence":"additional","affiliation":[{"name":"Hospital Barros Luco Trudeau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Nicol\u00e1s","family":"Medel","sequence":"additional","affiliation":[{"name":"Unidad de Pacientes Cr\u00edticos, Departamento de Medicina, Hospital Cl\u00ednico Universidad de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Petruska","sequence":"additional","affiliation":[{"name":"Hospital Barros Luco 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