{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:18:53Z","timestamp":1777853933167,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007338","name":"All India Institute of Medical Sciences","doi-asserted-by":"crossref","award":["A-195"],"award-info":[{"award-number":["A-195"]}],"id":[{"id":"10.13039\/501100007338","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:bold>Background:<\/jats:bold>\n                      Intravenous vitamin C has been evaluated as an adjunctive therapy in adults with septic shock, with mixed results. In pediatric patients, evidence remains limited and its role is yet to be defined.\n                      <jats:bold>Methods:<\/jats:bold>\n                      In this randomized, double-blind, placebo-controlled trial conducted in the pediatric intensive care unit (PICU) of a tertiary care hospital from February 2022 to March 2024, children &lt;17 years-old with septic shock were randomly assigned to receive either intravenous Vitamin C at 25\u2005mg\/kg every 6\u2005h for 72\u2005h or equal volumes of 5% dextrose as placebo. The primary outcome was change in pediatric sequential organ failure assessment (pSOFA) score at 72\u2005h from baseline. Secondary outcome was shock resolution and 28-day mortality.\n                      <jats:bold>Results:<\/jats:bold>\n                      Of 262 children with septic shock, 218 were randomized [median (IQR) age: 96 months (36.5, 133); 128 male]. The adjusted mean difference for change in pSOFA score at 72\u2005h between the Vitamin C and placebo groups was \u22120.51 [95% CI: (\u22121.76, 0.75)] (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.43)] (reduction in the Vitamin C group as compared to the placebo group). The 28-day mortality was comparable [Vitamin C, 21.6% versus placebo, 22.5%, RR: 0.96 (0.58-1.58),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.88]. There was no difference in shock resolution or any other outcomes. The incidence of prespecified adverse events (acute kidney injury) was similar in both groups.\n                      <jats:bold>Conclusion<\/jats:bold>\n                      Intravenous Vitamin C administration as adjunctive therapy in pediatric septic shock did not significantly impact organ dysfunction at 72\u2005h. Our findings do not support the routine use of Vitamin C as adjunctive therapy in septic shock in children.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial registration:<\/jats:bold>\n                      Clinical trial registry India (CTRI\/2020\/01\/022886).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666251362121","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T06:46:34Z","timestamp":1753425994000},"page":"147-155","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Vitamin C Versus Placebo in Pediatric Septic Shock (VITACiPS) - A Randomised Controlled Trial"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9807-6550","authenticated-orcid":false,"given":"Jhuma","family":"Sankar","sequence":"first","affiliation":[{"name":"Division of Pediatric Pulmonology and Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aravindhan","family":"Manoharan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology and Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2608-1163","authenticated-orcid":false,"given":"Rakesh","family":"Lodha","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology and Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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