{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:17:23Z","timestamp":1778948243716,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["The Dallas Fort Worth Living Legend Professorship"],"award-info":[{"award-number":["The Dallas Fort Worth Living Legend Professorship"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The EPIC deterioration index (EDI) and the Sequential Organ Failure Assessment (SOFA) scores are commonly used. However, no studies have examined their performance in hospitalized cancer patients just before intensive care unit (ICU) transfer. We examined the prognostic accuracy of the EDI and SOFA for 48-h ICU mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study evaluated consecutive hospitalized medical oncology patients transferred to the ICU from January 1, 2021 to December 31, 2023. Univariable and multivariable logistic regression models examined if EDI scores (EDI-now) and SOFA scores immediately prior to ICU transfer were predictive of 48-h ICU mortality. We assessed the performance of EDI-now, EDI at 24\u2005h before ICU transfer (EDI-24\u2005h), the difference between EDI-24\u2005h and EDI-now (EDI-change) and SOFA using the area under the receiver operating characteristic curve (AUROC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 1987 hospitalizations among 1907 unique patients (mean age\u2009=\u200961, male\u2009=\u200958%); 236 (11.9%) died within 48\u2005hours of ICU transfer. In the multivariable analysis, EDI-Now (OR [95% CI]; 3.11 [2.26,4.27], p\u2009&lt;\u20090.0001) and SOFA (OR [95% CI]; 1.78 [1.31,2.43], p\u2009=\u20090.0002) were significantly associated with 48-h ICU mortality. The AUROC for EDI-now, EDI-24\u2005h, EDI-change and SOFA were 0.657, 0.563, 0.635, and 0.621, respectively. The optimal cut-off threshold for EDI-now was 55 with 73.7% sensitivity, 54.4% specificity, 17.9% positive predictive value (PPV) and 91.5% negative predictive value (NPV). The optimal cut-off threshold for SOFA score was 5 with 63.1% sensitivity, 53.6% specificity, 15.5% PPV and 91.5% NPV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EDI-now\u2009\u2265\u200954.3 and SOFA\u2009\u2265\u20094 were associated with greater 48-h ICU mortality. High NPVs and low PPVs suggest EDI and SOFA scores could potentially be used to identify patients at lower risk of dying within 48\u2005hours but cannot be used to predict higher risk of 48-h mortality prior to ICU transfer. Better prognostic scores are needed for the medical oncology population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666251386399","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T16:16:41Z","timestamp":1760458601000},"page":"532-539","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of 48-h Intensive Care Unit Mortality in Hospitalized Cancer Patients: Performance of the EPIC Deterioration Index and Sequential Organ Failure Assessment Score"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7852-2306","authenticated-orcid":false,"given":"Cerena","family":"Leung","sequence":"first","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Cheng","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Walton","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico","family":"Nortje","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4507-4502","authenticated-orcid":false,"given":"Kerin","family":"Adelson","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2733-6607","authenticated-orcid":false,"given":"David","family":"Hui","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center"},{"name":"The University of Texas MD Anderson Cancer Center"},{"name":"The University of Texas MD Anderson Cancer Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.3131"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0354"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2020.09.001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.430"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v11.i10.809"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2018.03.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-49219-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0328"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181c0349e"},{"issue":"1","key":"e_1_3_2_11_2","first-page":"60","article-title":"Outcome of lung cancer patients admitted to the intensive care unit with acute respiratory failure","volume":"17","author":"Anisoglou S","year":"2013","unstructured":"Anisoglou S, Asteriou C, Barbetakis N, et al. 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