{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:05:04Z","timestamp":1780095904295,"version":"3.54.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with malignant neoplasms exhibit an elevated risk of sepsis and associated mortality. For septic patients with hemodynamic instability, early albumin administration is recommended, yet its specific impact in cancer-related sepsis remains unclear. This study aims to explore the relationship between early albumin administration and prognostic outcomes in patients with solid malignant neoplasms complicated by sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study employed a retrospective cohort analysis, utilizing data obtained from the Medical Information Mart for Intensive Care IV (MIMIC-IV v3.1) database. Patients were categorized into two groups: no-albumin and albumin. Within the albumin group, patients were further subclassified into early-albumin (infusion within 24\u2005h of ICU admission) and late-albumin (infusion more than 24\u2005h after ICU admission but before discharge). The primary endpoint was 28-day in-hospital mortality, while secondary endpoints including in-hospital mortality, length of hospital stay (Los_hospital), and length of ICU stay (Los_ICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 3700 eligible patients (2596 no-albumin; 1104 albumin), further subclassification within the albumin group revealed 736 early-albumin and 368 late-albumin patients. After propensity score matching (PSM), 312 pairs (early vs late) were analyzed. Cox regression models showed that early albumin administration significantly improved 28-day survival prospects. Compared to both no-albumin and late-albumin groups, the early-albumin group exhibited a pronounced survival advantage. Additionally, early albumin administration was associated with a shorter ICU stay. Subgroup analyses confirmed benefits across various demographics and clinical characteristics in the early-albumin group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early albumin administration within 24\u2005h of ICU admission significantly decreases 28-day and in-hospital mortality and shortens ICU stay in septic patients with solid malignant neoplasms. Our findings suggest that early albumin administration should be integrated into personalized resuscitation strategies for this high-risk population and merit further prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666251395595","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T17:33:28Z","timestamp":1764956008000},"page":"568-577","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Early Albumin Administration with 28-Day in-Hospital Mortality in Septic Patients with Solid Malignant Neoplasms: A Retrospective Cohort Analysis of the MIMIC-IV Database"],"prefix":"10.1177","volume":"41","author":[{"given":"Dezhi","family":"Shen","sequence":"first","affiliation":[{"name":"Sun Yat-sen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Ran","sequence":"additional","affiliation":[{"name":"The Fifth Affiliated Hospital, Sun Yat-sen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8861-3174","authenticated-orcid":false,"given":"Yajie","family":"Yu","sequence":"additional","affiliation":[{"name":"The Fifth Affiliated Hospital, Sun Yat-sen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaizhuang","family":"Huang","sequence":"additional","affiliation":[{"name":"Sun Yat-sen 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