{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T09:45:08Z","timestamp":1782726308002,"version":"3.54.5"},"reference-count":51,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Tien Shan Talents program of Xinjiang Uygur autonomous region","award":["2022TSYCCX0114"],"award-info":[{"award-number":["2022TSYCCX0114"]}]},{"name":"Natural Science Foundation of Xinjiang","award":["2022D01C843"],"award-info":[{"award-number":["2022D01C843"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current research indicated the comprehensive investigation of Annexin A3 (ANXA3) in sepsis patients remain uncertain. The aim of this research is to investigate the potential of ANXA3 as a biomarker for prediction of sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a meta-analysis utilizing public datasets from Gene Expression Omnibus (GEO) and Array Express database to summarize and evaluate the expression of ANXA3 in sepsis patients. Then, we conducted a retrospective study to explore the role of plasma ANXA3 in 153 critically ill patients. Furthermore, the predictive ability of ANXA3, procalcitonin (PCT), interleukin-6 (IL-6) and Sequential Organ Failure Assessment (SOFA) score for the occurrence of sepsis were evaluated using the Area Under the Curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Totally, the meta-analysis including 3241 sepsis and 1088 controls indicated sepsis patients were with markedly higher levels of ANXA3 mRNA expression (SMD\u2009=\u20092.01(1.54-2.48); P\u2009&lt;\u20090.001). Meanwhile, sepsis deaths (n\u2009=\u2009552) were with limited higher expression of ANXA3 mRNA than sepsis survivors (n\u2009=\u20092004) (SMD\u2009=\u20090.14(0.04-0.24); P\u2009&lt;\u20090.01). Furthermore, our results indicated increased plasma ANXA3 on admission were significantly associated with the incidence of sepsis in critically ill patients (OR\u2009=\u20092.41(1.75-3.32), P\u2009&lt;\u20090.001). As a predictive biomarker, plasma ANXA3 resulted in a better AUC 0.815(0.745-0.886) than PCT (0.673(0.584-0.761)) and IL-6 (0.672(0.585-0.759)) and SOFA score (0.668(0.577-0.759)). Additionally, patients with higher plasma ANXA3 had a poorer overall 28-day survival in critically ill patients (HR\u2009=\u20092.16(1.09-4.28); P\u2009&lt;\u20090.05), but not for sepsis patients (HR\u2009=\u20091.63(0.65-4.06); P\u2009&gt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study indicated increased ANXA3 obtained a good predictive ability for sepsis. Meanwhile, plasma ANXA3 was associated with mortality of critically ill patients, but not sepsis patients. The use of ANXA3 as a biomarker in sepsis patients require further evaluation in larger studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666251410538","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:38:01Z","timestamp":1768588681000},"page":"776-785","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of Annexin A3 as a Potential Biomarker for Sepsis in Critically Ill Patients: A Meta-analysis and Retrospective Cohort Study"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2541-0208","authenticated-orcid":false,"given":"Hong-xiang","family":"Lu","sequence":"first","affiliation":[{"name":"General Hospital of Xinjiang Military Region"},{"name":"Department of Trauma Medical Center, Daping Hospital, Army Medical University, Chongqing, 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Xinjiang Military Region"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xu","sequence":"additional","affiliation":[{"name":"General Hospital of Xinjiang Military Region"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-hai","family":"Shi","sequence":"additional","affiliation":[{"name":"General Hospital of Xinjiang Military Region"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Trauma Medical Center, Daping Hospital, Army Medical University, Chongqing, 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