{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:28:09Z","timestamp":1787610489590,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This paper was designed to investigate the clinical efficacy of combining the Average Volume Assured Pressure Support (AVAPS) mode of non-invasive ventilation (NIV) with high-flow nasal cannula oxygenation (HFNC) oxygen therapy in managing chronic obstructive pulmonary disease (COPD) patients complicated by respiratory failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety-six patients with COPD and respiratory failure were enrolled and classified into a control group and an observation group. Both groups received conventional treatment. The control group was treated with AVAPS-mode NIV, while the observation group received additional HFNC. Clinical outcomes, adverse reactions, clinical indicators, blood gas parameters, serum inflammatory markers, and pulmonary function indicators were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The observation group had a significantly higher overall clinical response rate (93.75% vs 75.00%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05), shorter ICU stays and mechanical ventilation times, lower respiratory rates, higher PaO\n                      <jats:sub>2<\/jats:sub>\n                      , SaO\n                      <jats:sub>2<\/jats:sub>\n                      , FEV\n                      <jats:sub>1<\/jats:sub>\n                      , FVC, and FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC values, and lower PaCO\n                      <jats:sub>2<\/jats:sub>\n                      , IL-6, IL-8, TNF-\u03b1, and sTREM-1 levels than the control group (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Heart rate did not differ significantly between the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&gt;\u20090.05). The adverse reaction rate was significantly lower in the observation group relative to the control group (4.17% vs 18.75%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This combined approach demonstrates superior efficacy in treating COPD patients with respiratory failure, improving arterial blood gas and pulmonary function, reducing inflammatory responses, and exhibiting a high safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666251412806","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:15:41Z","timestamp":1767986141000},"page":"845-852","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Superiority of AVAPS Mode of Non-invasive Ventilation in Combination with HFNC Over HFNC Alone in Patients with Chronic Obstructive Pulmonary Disease Complicated by Respiratory Failure"],"prefix":"10.1177","volume":"41","author":[{"given":"Jiaojiao","family":"Yang","sequence":"first","affiliation":[{"name":"The First People's Hospital of Nantong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyan","family":"Ren","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Nantong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Yu","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Nantong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfen","family":"Chen","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Nantong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0054-1397","authenticated-orcid":false,"given":"Guixiang","family":"Qin","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Nantong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00132-2017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00164-2019"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.09.049"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2023.2208886"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13514"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.21037\/apm-22-272"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2023.12.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2023-002144"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.5578\/tt.20229810"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2020.07.002"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2022.154250"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.5578\/tt.20229603"},{"issue":"12","key":"e_1_3_2_14_2","article-title":"Role of average volume assured pressure support mode (AVAPS) in the management of acute exacerbation of chronic obstructive pulmonary disease with type 2 respiratory failure","volume":"14","author":"Maheshwari A","year":"2022","unstructured":"Maheshwari A, Khatri J, Soni G, et al. Role of average volume assured pressure support mode (AVAPS) in the management of acute exacerbation of chronic obstructive pulmonary disease with type 2 respiratory failure. 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Impact of high-flow nasal cannula on arterial blood gas parameters in the emergency department. Cureus. 2020;12(9):e10516.","journal-title":"Cureus"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3233\/THC-213609"},{"issue":"3","key":"e_1_3_2_26_2","first-page":"271","article-title":"Effect of humidified high-flow nasal cannula oxygen therapy with a pulmonary infection control window as a ventilation switching indication in combination with atomizing inhalation of terbutaline on the lung function of patients with acute exacerbation of COPD","volume":"78","author":"Ye M","year":"2024","unstructured":"Ye M, Zhang R. Effect of humidified high-flow nasal cannula oxygen therapy with a pulmonary infection control window as a ventilation switching indication in combination with atomizing inhalation of terbutaline on the lung function of patients with acute exacerbation of COPD. 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