{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:45:31Z","timestamp":1791888331084,"version":"4.3.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Targeted temperature management (TTM) is the standard of care for comatose cardiac arrest survivors. However, evidence regarding its long-term neurological impact specifically on in-hospital cardiac arrest (IHCA) survivors remains limited. This study investigated the association between TTM and the risk of new-onset brain disability in adult IHCA survivors using a \u201chard\u201d endpoint derived from a national registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This nationwide retrospective cohort study utilized the South Korean National Health Insurance Service database (2013-2022). Adult IHCA survivors were categorized into TTM and non-TTM groups. The primary endpoint was newly diagnosed brain disability registered in the Korea National Disability Registration System. This endpoint requires stringent certification by board-certified specialists after at least six months of active treatment to confirm irreversibility. We performed 1:5 propensity score matching and used stratified Cox proportional hazards models to estimate hazard ratios (HR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 95\u2005337 eligible survivors, 31\u2005592 patients were included in the matched cohort (5633 TTM vs 25\u2005959 non-TTM). The TTM group showed a significantly lower incidence of new-onset brain disability compared with the non-TTM group (5.0% vs 5.2%). In the PS-matched analysis, TTM was independently associated with a reduced risk of new-onset brain disability (HR, 0.85; 95% confidence interval [CI], 0.75-0.96;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.012). Multivariable sensitivity analysis in the entire cohort confirmed this protective association (adjusted HR, 0.80; 95% CI, 0.70-0.90;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large-scale nationwide cohort of IHCA survivors, TTM implementation was associated with a decreased risk of legally certified, permanent brain disability. These findings provide real-world evidence supporting the continued use of TTM as a neuroprotective strategy to improve long-term quality of survivorship in the IHCA population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666261434483","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:31:07Z","timestamp":1776263467000},"page":"1135-1143","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Targeted Temperature Management and New-Onset Brain Disability in in-Hospital Cardiac Arrest Survivors: A Nationwide Cohort Study"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-4423","authenticated-orcid":false,"given":"Tak Kyu","family":"Oh","sequence":"first","affiliation":[{"name":"Seoul National University Bundang Hospital"},{"name":"Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7814-4253","authenticated-orcid":false,"given":"In-Ae","family":"Song","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital"},{"name":"Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2022.04.023"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.1696"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.09.017"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109148"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001373"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06368-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100591"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1906661"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-3403"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000702"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182340239"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"issue":"2","key":"e_1_3_3_14_2","article-title":"Cohort profile: The national health insurance service\u2013national sample cohort (NHIS-NSC), South Korea","volume":"46","author":"Lee J","year":"2017","unstructured":"Lee J, Lee JS, Park S-H, Shin SA, Kim K. 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