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This study aims to evaluate these differences following the adjustment of the \u201czero-COVID\u201d policy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted using propensity score matching (PSM). We enrolled adult patients with non-COVID-19 severe pneumonia (2016-2021) and severe\/critical COVID-19 (Omicron wave, 2022-2023). AKI was defined according to KDIGO criteria based on serum creatinine (SCr). The primary outcome was AKI incidence; secondary outcomes included severe AKI, continuous renal replacement therapy (CRRT) use, and in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 845 non-COVID-19 and 396 severe COVID-19 patients were screened. After 1:1 matching, 300 pairs were analyzed. The incidence of AKI was similar between groups (49.0% in non-COVID-19 vs 51.3% in COVID-19,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.603). However, severe COVID-19 patients had significantly higher rates of severe AKI (34.0% vs 25.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.034), CRRT use (8.7% vs 3.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.017), and in-hospital mortality (29.3% vs 19.3%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.006). Multivariate analysis showed that Omicron infection was an independent risk factor for in-hospital death (OR\u2009=\u20092.096, 95% CI: 1.231-3.567,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.006) and CRRT use (OR\u2009=\u20095.907, 95% CI: 1.662-20.997,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the overall incidence of AKI was similar after matching, severe COVID-19 (Omicron) patients suffered from more severe kidney injury and worse clinical outcomes compared to non-COVID-19 severe pneumonia patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666261434538","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:55:24Z","timestamp":1784040924000},"page":"1113-1123","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Differences in Clinical Characteristics, Incidence, and Prognosis of Acute Kidney Injury Between Patients with Severe Pneumonia of COVID-19 and non-COVID-19 During the Omicron"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8173-551X","authenticated-orcid":false,"given":"Weijuan","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Nephrology, Jiujiang No. 1 People's Hospital, Jiujiang, Jiangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China"},{"name":"Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China"},{"name":"Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000349"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.2089"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01511-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-020-03775-x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-3071"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500245"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066619826045"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc4927"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2167-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa270"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020050615"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04650420"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.05.006"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1996"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020040509"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.3596"},{"key":"e_1_3_3_19_2","unstructured":"State Department joint prevention and control mechanism. 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