{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T08:11:41Z","timestamp":1778487101842,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-115"],"award-info":[{"award-number":["2022-PUMCH-B-115"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-D-005"],"award-info":[{"award-number":["2022-PUMCH-D-005"]}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L222019"],"award-info":[{"award-number":["L222019"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFF1207104"],"award-info":[{"award-number":["2024YFF1207104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801901"],"award-info":[{"award-number":["81801901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"College Innovation Fund for Medical Sciences","award":["2024-I2M- C&T-C-002"],"award-info":[{"award-number":["2024-I2M- C&T-C-002"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate effects of platelet transfusion on sepsis associated thrombocytopenia (SAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, 695 SAT patients admitted to Peking Union Medical College Hospital (PUMCH) were enrolled from June 8, 2013 to October 12, 2022. Externally validate was carried out using 2739 SAT patients in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients were divided into 2 groups based on whether platelet transfusion was administered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After propensity score-matching, compared with the control group, the platelet transfusion group had longer mechanical ventilation time (43 vs 169\u2005h, P\u2009&lt;\u20090.05), more expenses (122.29 vs 254.03 thousand yuan [RMB], P\u2009&lt;\u20090.05), longer hospital stays (536 vs 817\u2005h, P\u2009&lt;\u20090.05), longer hospital stays after diagnosis of SAT (384 vs 636\u2005h, P\u2009&lt;\u20090.05), longer ICU stays (133 vs 227\u2005h, P\u2009&lt;\u20090.05), higher mortality (30.1 vs 53.4%, P\u2009&lt;\u20090.05). Effective platelet transfusion rate was 52.51%. Subgroup analysis based on the degree of thrombocytopenia and data analysis from MIMIC-IV further confirmed above results. Contrary to intuition, as the platelet count decreased, the effective platelet transfusion rate tended to decrease. Positive rate of deep vein thrombosis (DVT) was 18.85% in SAT in PUMCH. Compared with the control group, the platelet transfusion group had higher positive rate of DVT (27 \/ 131 vs 33 \/ 92, P\u2009&lt;\u20090.05) in subgroup with platelet count [50, 100\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L) in PUMCH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      No benefits from platelet transfusion were observed in SAT. Around 50% of platelet transfusions in SAT were platelet transfusion refractoriness. Platelet transfusion was associated with higher positive rate of DVT in SAT patients with platelet count [50, 100\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666261448808","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T12:55:27Z","timestamp":1778158527000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Platelet Transfusion on Sepsis Associated Thrombocytopenia (SAT): A Multicenter Retrospective Chart Review"],"prefix":"10.1177","author":[{"given":"Lu","family":"Wang","sequence":"first","affiliation":[{"name":"Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Pan","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Du","sequence":"additional","affiliation":[{"name":"Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4291-5108","authenticated-orcid":false,"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences"},{"name":"Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"On behalf of China National Critical Care Quality Control Centre Group (China-NCCQC) and China Critical Care Clinical Trials Group (CCCCTG)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05556-8"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05585-3"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/10760296241283166"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2025-099691"},{"issue":"2","key":"e_1_3_4_6_2","article-title":"China National critical care quality control centre G: Factors influencing sepsis associated thrombocytopenia (SAT): A multicenter retrospective cohort study","volume":"20","author":"Wang L","year":"2025","unstructured":"Wang L, Chen J, Zhou X. 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Chinese Expert consensus on the diagnosis and management of platelet transfusion refractoriness (2022). Zhonghua Xue Ye Xue Za Zhi. 2022;43(11):897\u2013902. https:\/\/doi.10.3760\/cma.j.issn.0253-2727.2022.11.003","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-2-42"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05884-8"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13549"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/1076029620959467"},{"issue":"5","key":"e_1_3_4_17_2","article-title":"Sepsis and thrombocytopenia: A nowadays problem","volume":"14","author":"Gonzalez DA","year":"2022","unstructured":"Gonzalez DA, Kumar R, Asif S, Bali A, Dang AK. Sepsis and thrombocytopenia: A nowadays problem. 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