{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T08:04:24Z","timestamp":1779609864528,"version":"3.53.1"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The furosemide stress test is useful for predicting acute kidney injury (AKI) progression, but its widespread use is limited by concerns regarding adverse events associated with high-dose administration (1-1.5\u2005mg\/kg). Furosemide responsiveness (FR) to lower doses seems to have high predictive value while reducing such risks, but its utility in early-stage AKI (stage 1) is unclear. We thus investigated the predictive value of FR in early-stage AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed adult intensive-care unit patients (\u226518 years old) admitted between January 2021 and June 2024 who received a furosemide bolus dose during stage 1 of AKI. FR was assessed using the FR index (FRI; 2-h urine output per furosemide dose), body weight-adjusted FRI (mFRI), and body weight-adjusted 2-h urine output (UO\/BW). The indices were compared by the Mann\u2013Whitney U test between progression (stage \u22652 within 7 days) and non-progression groups, and predictive ability was assessed by a receiver operating characteristic (ROC) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 50 patients, 12 progressed and 38 did not. The mean furosemide dose was 0.29\u2005mg\/kg. FRI, mFRI, and UO\/BW were significantly lower in the progression group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), with respective areas under the ROC curve of 0.945 (95% confidence interval, 0.887-1.000), 0.921 (0.831-1.000), and 0.919 (0.842-0.996). No hypotension requiring a rescue fluid bolus or other clinically overt hemodynamic instability was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FR to lower doses was associated with subsequent progression from AKI stage 1 without evident hemodynamic instability in this cohort. These findings suggest that FR may provide a potentially safe and clinically useful indicator for early risk stratification in critically ill patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666261454595","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:54:59Z","timestamp":1779299699000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of the Diuretic Response to Low-Dose Furosemide for Predicting Progression from Acute Kidney Injury Stage 1 in Critically Ill Patients: A Retrospective Cohort Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1643-8499","authenticated-orcid":false,"given":"Jumpei","family":"Kohara","sequence":"first","affiliation":[{"name":"Kyoto University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Mizota","sequence":"additional","affiliation":[{"name":"Kyoto University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Kyoto University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritoki","family":"Egi","sequence":"additional","affiliation":[{"name":"Kyoto University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.339"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61454-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a5906f"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfab263"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09430913"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00910116"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc13015"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014060535"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2019.04.011"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-018-0355-0"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2023.07.011"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-024-01387-y"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2025.155171"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2012.20"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4670-3"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2020.11.002"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005849"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-024-01349-4"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000495765"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2024.155002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-020-00339-8"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.07.030"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005419"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2021.1906701"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02385-7"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666261454595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08850666261454595","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666261454595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T07:21:10Z","timestamp":1779607270000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08850666261454595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":25,"alternative-id":["10.1177\/08850666261454595"],"URL":"https:\/\/doi.org\/10.1177\/08850666261454595","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"article-number":"08850666261454595"}}