{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:14:22Z","timestamp":1781532862038,"version":"3.54.5"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Use of vasoactive medications is common in pediatric intensive care units (ICUs), however evidence to guide medication selection is limited likely resulting in practice variation. Our objective was to describe the use of vasoactive infusions across ICUs and sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study using the multi-institutional PICU Data Collaborative (PDC) database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Four pediatric ICUs (PICUs) and three cardiac ICUs (CICUs) from the U.S. participating in the PDC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Patients admitted to a participating ICU between 2010 and 2022 who received a vasoactive infusion within 7 days of ICU admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>None.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results<\/jats:title>\n                    <jats:p>A vasoactive infusion was administered within the first 7 days of admission in 16,959 (22%) out of a total of 75,953 ICU encounters. CICU encounters comprised 20% of all ICU encounters but 60% of those with a vasoactive infusion. The most frequently used vasoactive medications were milrinone (63%) and epinephrine (59%). We found a statistically significant difference in the frequency of each vasoactive infusion between PICU sites (P\u2009&lt;\u20090.001) and between CICU sites (P\u2009&lt;\u20090.001). The median peak vasoactive inotrope score (VIS) was 10 [IQR 5.5\u201320] and 8 [IQR 5\u201312.5] among PICU and CICU encounters respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found significant variability in the frequency of vasoactive infusion medication use between sites and type of ICU. Further investigation is needed to understand what impact this practice variability has on patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666261459351","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:40:17Z","timestamp":1781329217000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Variability in Vasoactive Medication use Across Pediatric Intensive Care Units: A PICU Data Collaborative Study, 2010\u20132022"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-0704","authenticated-orcid":false,"given":"Stephanie R.","family":"Brown","sequence":"first","affiliation":[{"name":"Emory University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Heneghan","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7822-1669","authenticated-orcid":false,"given":"Colleen","family":"Badke","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Dziorny","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alysia","family":"Flynn","sequence":"additional","affiliation":[{"name":"Laura P. and Leland K. Whittier Virtual Pediatric Intensive Care Unit, University of Southern California Keck School of Medicine, Children's Hospital Los Angeles, Los Angeles, CA. US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid W.D.","family":"Farris","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine, Seattle Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tellen D.","family":"Bennett","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine, Children's Hospital Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tawfik","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine, Lucile Packard Children's Hospital Stanford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy T.","family":"Cornell","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine, Lucile Packard Children's Hospital Stanford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Laura P. and Leland K. Whittier Virtual Pediatric Intensive Care Unit, University of Southern California Keck School of Medicine, Children's Hospital Los Angeles, Los Angeles, CA. US"},{"name":"Departments of Pediatrics and Anesthesiology (Critical Care Medicine), University of Southern California Keck School of Medicine, Children's Hospital Los Angeles, Los Angeles, CA. US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nishisaki","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Rogerson","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine"},{"name":"Regenstrief Institute, Indianapolis, Indiana. US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"3","article-title":"Epidemiology of pediatric septic shock","volume":"8","author":"Souza D","year":"2018","unstructured":"Souza D, Machado FR. Epidemiology of pediatric septic shock. JPediatr Intensive Care. 2018;8(1):3-10. doi:https:\/\/doi.org\/10.1055\/s-0038-1676634","journal-title":"JPediatr Intensive Care."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-016-0111-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.00000000000021984"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000635"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000003758"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001191"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0196"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000954"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001260"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001120"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000003086"}],"container-title":["Journal of Intensive Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666261459351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08850666261459351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08850666261459351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:48:03Z","timestamp":1781531283000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08850666261459351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":11,"alternative-id":["10.1177\/08850666261459351"],"URL":"https:\/\/doi.org\/10.1177\/08850666261459351","relation":{},"ISSN":["0885-0666","1525-1489"],"issn-type":[{"value":"0885-0666","type":"print"},{"value":"1525-1489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]},"article-number":"08850666261459351"}}