{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:45:38Z","timestamp":1785703538321,"version":"3.56.0"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Evaluate the association between intubation location (within the ICU vs outside the ICU) and early sedation practices, specifically sedation depth and medication exposure during the first 24\u2005h of care and subsequent patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a single- center, retrospective cohort study in a medical ICU at a tertiary academic medical center. Included patients were adults requiring mechanical ventilation, receiving continuous infusion sedatives for &gt;24\u2005h. Exclusion criteria during the first 24\u2005h: death, end of life care, neuromuscular blocking agents beyond intubation, alcohol withdrawal syndrome, ST-elevation or Type-1 non-ST elevation myocardial infarction, targeted temperature management, seizure, or intracranial pressure monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred-thirty patients were included. Sixty-eight patients (29.6%) were intubated in the ICU and 162 (70.4%) were intubated outside the ICU. Patients intubated in the ICU had an initial RASS score of \u22124 (IQR \u22124 to \u22122) versus \u22123 (IQR \u22124 to \u22122) in the outside of ICU intubation group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.44). The total time in deep sedation during the first 24\u2005h was 16.8\u2005h (IQR 11.6-21.8) versus 12\u2005h (IQR 6.7-20) respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.02). There was no difference in sedative use or sedation exposure between cohorts. Duration of mechanical ventilation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.65), hospital (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.05) and ICU length of stay (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.19) showed no difference. Illness severity scores were no different between cohorts on admission (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.28); however, intubation in the ICU had higher ICU (45.6% vs 20.4%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and hospital (32.4% vs 13.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Location of intubation was not associated with depth of sedation or medication exposure during the first 24\u2005h of ICU care.<\/jats:p>\n                  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