{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:45:23Z","timestamp":1792752323802,"version":"4.5.0"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"\"From 0 To 1\" Innovation Research Project of Sichuan University","award":["2023SCUH0065"],"award-info":[{"award-number":["2023SCUH0065"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2411800"],"award-info":[{"award-number":["2023YFC2411800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82670934"],"award-info":[{"award-number":["82670934"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"135 Project for Disciplines of Excellence of West China Hospital","award":["2025HXFH050"],"award-info":[{"award-number":["2025HXFH050"]}]},{"name":"Sichuan Provincial Health Commission","award":["2025-106"],"award-info":[{"award-number":["2025-106"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Intensive Care Med"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The albumin\u2013bilirubin index (ALBI) has been reported as a prognostic marker in various clinical conditions; however, its value in patients with septic acute kidney injury (AKI) has not been clearly evaluated. This study aimed to investigate the association between ALBI and clinical outcomes in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used data from the Medical Information Mart for Intensive Care IV database. ALBI was analyzed as both a continuous variable in the primary analysis and a categorical variable according to tertiles in sensitivity analysis. The primary outcomes were 28-day, 60-day, 90-day, and 1-year all-cause mortality. Secondary outcomes included intensive care unit (ICU) transfer, septic shock, and disease severity. Cox proportional hazards models were used to evaluate the association between ALBI and mortality, and restricted cubic spline analyses were performed to assess potential nonlinearity. Subgroup analyses were further conducted to examine the consistency across different sub-group populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 6700 patients with septic AKI were included. In adjusted Cox models, each 1-standard deviation increase in ALBI was associated with higher risks of 28-day mortality (HR 1.16, 95% confidence interval [CI] 1.10-1.22), 60-day mortality (HR 1.14, 95% CI 1.10-1.19), 90-day mortality (HR 1.13, 95% CI 1.08-1.18), and 1-year mortality (HR 1.10, 95% CI 1.06-1.14). The association between ALBI and mortality was generally consistent across most prespecified subgroups. Higher ALBI was also linked with septic shock (odds ratio [OR] 1.15, 95%CI 1.08-1.21, P\u2009&lt;\u2009.001), ICU transfer (OR 1.09, 95%CI 1.02-1.16), and greater disease severity. RCS curves showed a nonlinear increase in mortality risk with ascending ALBI. Sensitivity analyses based on ALBI tertiles yielded broadly consistent findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher ALBI was independently associated with increased short- and long-term mortality and adverse clinical outcomes in septic AKI patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08850666261498162","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:07:45Z","timestamp":1792422465000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Albumin\u2013Bilirubin Index and Clinical Outcomes in Septic Acute Kidney Injury Patients"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3531-188X","authenticated-orcid":false,"given":"Caihong","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Wu","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University\/West China School of Nursing, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyao","family":"Yang","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University\/West China School of Nursing, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiu","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanlin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglei","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University\/West China School of Nursing, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letian","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-452X","authenticated-orcid":false,"given":"Yuliang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Kidney Diseases, West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0289"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.05.026"},{"key":"e_1_3_4_4_2","unstructured":"Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup | Nature Reviews Nephrology. 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