{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:37:24Z","timestamp":1777786644494,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>The aim of the present study is to evaluate the effects of intraosseous implantation of silica-based bioactive glass (BG) particles on rat kidney under experimental renal failure. The animals are assigned to one of the two groups: renal failure (RF) and renal failure + bioactive glass (RF + BG). Particles of melt-derived 45S5 BG are implanted in the marrow of one tibia of each animal in the RF + BG group. The animals are killed 24 h and 14 days postimplantation. The RF + BG group exhibits a statistically significant increase in serum urea 24 h postimplantation. The tibiae of the RF + BG group are resected and embedded in methyl-methacrylate resin. Ground sections are analyzed by light microscopy and energy-dispersive X-ray (EDX) analysis. The presence of silicon, calcium, and phosphorus is evaluated in the BG particles. A 55% reduction in silicon content is observed at 14 days postimplantation as compared with that at 24 h.<\/jats:p>\n                  <jats:p>Light microscopy analysis reveals lesions in kidney parenchyma. Hyperplasia associated with nuclear vacuolization in the tubules and a marked thickening of the basal membrane are observed in the renal cortex of the RF + BG animals killed at 24 h postimplantation, but not in those at 14 days.<\/jats:p>\n                  <jats:p>The present results demonstrate reversible renal cell injury in rats exposed to intraosseous implantation of silica-based BG particles under experimental RF.<\/jats:p>","DOI":"10.1177\/0885328206068061","type":"journal-article","created":{"date-parts":[[2007,4,23]],"date-time":"2007-04-23T06:52:42Z","timestamp":1177311162000},"page":"431-442","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Intraosseous Implantation of Silica-based Bioactive Glass                 Particles on Rat Kidney under Experimental Renal Failure"],"prefix":"10.1177","volume":"21","author":[{"given":"Alejandro A.","family":"Gorustovich","sequence":"first","affiliation":[{"name":"Research Laboratory, National Atomic Energy Commission Regional Noroeste,                         Av. Bolivia 4650 (A4408FVT) Salta, Argentina,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto J.","family":"Monserrat","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine University of Buenos Aires,                         Jos\u00e9 E. Uriburu 950 (C1114AAD) Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria B.","family":"Guglielmotti","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry University of Buenos                         Aires, Marcelo T. de Alvear 2142, 2A (C1122AAH) Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romulo L.","family":"Cabrini","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, School of Dentistry University of Buenos                         Aires, Marcelo T. de Alvear 2142, 2A (C1122AAH) Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067404"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00339-9"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008949527695"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00546-5"},{"issue":"4","key":"atypb5","first-page":"543","volume":"15","author":"Hench, L.L.","year":"2004","journal-title":"Polym"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00044-9"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00181-7"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200105)55:2<151::AID-JBM1001>3.0.CO;2-D"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00288-X"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.07.001"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.09.059"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30241"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.08.054"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820260207"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(92)90067-X"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00097-7"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-2586-6_1"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-120026028"},{"issue":"5","key":"atypb19","first-page":"644","volume":"17","author":"Gorustovich, A.","year":"2002","journal-title":"Int. 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