{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:01:42Z","timestamp":1777788102461,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T00:00:00Z","timestamp":1376352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Gastrointestinal endoscopy is a standard diagnostic tool for gastrointestinal ulcers and cancer. In this study, we have developed recombinant human epidermal growth factor-containing ulcer-coating polymeric sol\u2013gel for endoscopic application. Chitosan and pluronic F127 were employed for their thermoresponsive and bioadhesive properties. At temperatures below 21\u2103, polymeric sol\u2013gel remains liquid during endoscopic application and transforms to gel at body temperature after application on ulcers. In an in\u00a0vitro cellular wounding assay, recombinant human epidermal growth factor sol\u2013gel significantly enhanced the cell migration and decreased the wounding area (68%) compared to nontreated, recombinant human epidermal growth factor solution, and sol\u2013gel without recombinant human epidermal growth factor (42, 49, and 32 % decreased at day 1). The in\u00a0vivo ulcer-healing study was performed in an acetic acid-induced gastric ulcer rat model and proved that our recombinant human epidermal growth factor endoscopic sol\u2013gel facilitated the ulcer-healing process more efficiently than the other treatments. Ulcer sizes in the recombinant human epidermal growth factor sol\u2013gel group were decreased 2.9- and 2.1-fold compared with those in the nontreated group on days 1 and 3 after ulceration, respectively. The mucosal thickness in the recombinant human epidermal growth factor sol\u2013gel group was significantly increased compared to that in the nontreated group (3.2- and 6.9-fold on days 1 and 3 after ulceration, respectively). In a gastric retention study, recombinant human epidermal growth factor sol\u2013gel stayed on the gastric mucosa more than 2\u2009h after application. The present study suggests that recombinant human epidermal growth factor sol\u2013gel is a prospective candidate for treating gastric ulcers via endoscopic application.<\/jats:p>","DOI":"10.1177\/0885328213499948","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T20:35:59Z","timestamp":1376426159000},"page":"1113-1121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["rhEGF-containing thermosensitive and mucoadhesive polymeric sol\u2013gel for endoscopic treatment of gastric ulcer and bleeding"],"prefix":"10.1177","volume":"28","author":[{"given":"Jin Hee","family":"Maeng","sequence":"first","affiliation":[{"name":"Utah-Inha DDS and Advanced Therapeutics Research Center, Incheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Won","family":"So","sequence":"additional","affiliation":[{"name":"CG Bio Research Institute, Sungnam, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungju","family":"Kim","sequence":"additional","affiliation":[{"name":"CG Bio Research Institute, Sungnam, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Ae","family":"Kim","sequence":"additional","affiliation":[{"name":"Life Science Research Institute, Daewoong Pharmaceutical Co., Ltd., Yongin, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hoon","family":"Jung","sequence":"additional","affiliation":[{"name":"Life Science Research Institute, Daewoong Pharmaceutical Co., Ltd., Yongin, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyunghyun","family":"Min","sequence":"additional","affiliation":[{"name":"Life Science Research Institute, Daewoong Pharmaceutical Co., Ltd., Yongin, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don Haeng","family":"Lee","sequence":"additional","affiliation":[{"name":"Utah-Inha DDS and Advanced Therapeutics Research Center, Incheon, Korea"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Inha University Hospital, Incheon, Korea"},{"name":"Department of new drug development and NCEED, School of Medicine, Inha University, Incheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Geun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of new drug development and NCEED, School of Medicine, Inha University, Incheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,8,13]]},"reference":[{"key":"bibr1-0885328213499948","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00723.x"},{"key":"bibr2-0885328213499948","doi-asserted-by":"crossref","unstructured":"Chai J. Gastric ulcer healing\u2014role of serum response factor.\n                      Peptic Ulcer Dis.\n                      In: Jianyuan Chai (ed.). Rijeka, Croatia: InTech 2011; 143\u2013164.","DOI":"10.5772\/17410"},{"key":"bibr3-0885328213499948","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-7-8"},{"key":"bibr4-0885328213499948","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01393.x"},{"key":"bibr5-0885328213499948","doi-asserted-by":"publisher","DOI":"10.1002\/j.2055-2335.2011.tb00069.x"},{"key":"bibr6-0885328213499948","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.055012"},{"key":"bibr7-0885328213499948","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.080754"},{"key":"bibr8-0885328213499948","doi-asserted-by":"crossref","unstructured":"Holster IL and Kuipers EJ. 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