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A 4-armed PPO\/PEO-phenol conjugate by a non-degradable linker was synthesized to form a hydrogel in situ by horseradish peroxidase. The gelation time and modulus could be controlled, ranging from 20\u2009s to 2\u2009min and from 1 to 43\u2009kPa. The adhesion of human lens epithelial cells on the hydrogel was significantly reduced compared to that on commercial IOLs. The hydrogels were injected into the rabbit eyes to evaluate the in\u00a0vivo biocompatibility for 8 weeks. Corneal endothelial cell loss and central corneal thickness were comparable with the common IOL implantation procedure. Histologically, the cornea and retina showed the intact structure. The change of refraction after application of pilocarpine was +0.42 D preoperatively and +0.83 D postoperatively, which may indicate the maintenance of accommodation amplitude.<\/jats:p>","DOI":"10.1177\/0885328213505247","type":"journal-article","created":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T02:00:43Z","timestamp":1379642443000},"page":"1247-1263","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Fast in situ enzymatic gelation of PPO-PEO block copolymer for injectable intraocular lens in\u00a0vivo"],"prefix":"10.1177","volume":"28","author":[{"given":"Hanna","family":"Lee","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chonnam 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