{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:50:44Z","timestamp":1790045444968,"version":"4.0.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T00:00:00Z","timestamp":1412208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Biodegradable magnesium metal filaments placed inside biodegradable nerve conduits might provide the physical guidance support needed to improve the rate and extent of regeneration of peripheral nerves across injury gaps. In this study, we examined basic issues of magnesium metal resorption and biocompatibility by repairing sub-critical size gap injuries (6\u2009mm) in one sciatic nerve of 24 adult male Lewis rats. Separated nerve stumps were connected with poly(caprolactone) nerve conduits, with and without magnesium filaments (0.25\u2009mm diameter, 10\u2009mm length), with two different conduit filler substances (saline and keratin hydrogel). At 6 weeks after implantation, magnesium degradation was examined by micro-computed tomography and histological analyses. Magnesium degradation was significantly greater when the conduits were filled with an acidic keratin hydrogel than with saline ( p\u2009&lt;\u20090.05). But magnesium filaments in some animals remained intact for 6 weeks. Using histological and immunocytochemical analyses, good biocompatibility of the magnesium implants was observed at 6 weeks, as shown by good development of regenerating nerve mini-fascicles and only mild inflammation in tissues even after complete degradation of the magnesium. Nerve regeneration was not interrupted by complete magnesium degradation. An initial functional evaluation, determination of size recovery of the gastrocnemius muscle, showed a slight improvement due to magnesium with the saline but not the keratin filler, compared with respective control conduits without magnesium. These results suggest that magnesium filament implants have the potential to improve repair of injured peripheral nerve defects in this rodent model.<\/jats:p>","DOI":"10.1177\/0885328214553135","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T23:42:56Z","timestamp":1412379776000},"page":"1145-1154","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Initial observations on using magnesium metal in peripheral nerve repair"],"prefix":"10.1177","volume":"29","author":[{"given":"JJ","family":"Vennemeyer","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, University of Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, University of Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hershcovitch","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, University of Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KD","family":"Little","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MC","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Minteer","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DB","family":"Hom","sequence":"additional","affiliation":[{"name":"Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology\u2014Head & Neck Surgery and Dermatology, University of Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Department of Plastic Surgery, University of Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SK","family":"Pixley","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, University of Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,10,2]]},"reference":[{"key":"bibr1-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200006)23:6<863::AID-MUS4>3.0.CO;2-0"},{"key":"bibr2-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2010.0184"},{"key":"bibr3-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v39.i2.20"},{"key":"bibr4-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.12.030"},{"key":"bibr5-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2011.0498"},{"key":"bibr6-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.10.002"},{"key":"bibr7-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1163\/156856207781494386"},{"key":"bibr8-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.04.022"},{"key":"bibr9-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1179\/016164104225013798"},{"key":"bibr10-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.02.028"},{"key":"bibr11-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1179\/1743278212Y.0000000034"},{"key":"bibr12-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-12-62"},{"key":"bibr13-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-013-1362-7"},{"key":"bibr14-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1684\/mrh.2009.0175"},{"key":"bibr15-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20215"},{"key":"bibr16-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2009.12.001"},{"issue":"8","key":"bibr17-0885328214553135","first-page":"65","volume":"14","author":"Hoane MR","year":"2004","journal-title":"Clin Calcium"},{"key":"bibr18-0885328214553135","doi-asserted-by":"publisher","DOI":"10.1684\/mrh.2011.0280"},{"key":"bibr19-0885328214553135","doi-asserted-by":"crossref","unstructured":"Vennemeyer JJ, Hopkins T, Kuhlmann J, et\u00a0al. 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