{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:05:32Z","timestamp":1777788332293,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>Polymethylmethacrylate-based bone cements are widely used for fixation of joint replacements. To improve the long-term outcome, bioactive bone cements are aspired to advance the bone\u2013cement interface. This study evaluated the in vivo properties of a new polymethylmethacrylate-based bioactive bone cement with addition of amphiphilic phosphorylated 2-hydroxyethylmethacrylate. Previous in vitro studies confirmed bioactive properties in cell culture, as well as unchanged mechanical properties are tests according to ISO 5833:2002.<\/jats:p>\n                  <jats:p>\n                    Three different variations of the cement (polymethylmethacrylate\u2009+\u2009phosphorylated 2-hydroxyethylmethacrylate, polymethylmethacrylate\u2009+\u2009phosphorylated 2-hydroxyethylmethacrylate\u2009+\u2009CaCl\n                    <jats:sub>2<\/jats:sub>\n                    and polymethylmethacrylate\u2009+\u2009phosphorylated 2-hydroxyethylmethacrylate\u2009+\u2009CaCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2009+\u2009Na\n                    <jats:sub>2<\/jats:sub>\n                    CO\n                    <jats:sub>3<\/jats:sub>\n                    ) were compared to conventional polymethylmethacrylate cement. To evaluate the properties under load-bearing conditions, a spacer prosthesis was implanted into the femoral diaphysis of 24 rabbits. Additionally, a cement plug was installed into the proximal tibia. After three months, polished sections with Giemsa surface staining were prepared. The bioactivity was determined using the bone affinity index.\n                  <\/jats:p>\n                  <jats:p>The sections showed a good osseointegration of the bioactive bone cement without cement cracks under load-bearing conditions. Regarding the bone affinity index, the bioactive bone cement revealed a significantly higher value in the proximal tibia (25.9\u201337.7%) and around the spacer prosthesis (36.8\u201358.9%) compared to the conventional polymethylmethacrylate cement (12.8\u201317.0%).<\/jats:p>\n                  <jats:p>The results confirm the in vivo bioactivity of this bone cement. The absence of cement cracks indicates a sufficient mechanical stability to fix prostheses with this bioactive cement, but for a final assessment long-term tests are necessary.<\/jats:p>","DOI":"10.1177\/0885328215569092","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T20:13:12Z","timestamp":1422389592000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["In vivo evaluation of bioactive PMMA-based bone cement with unchanged mechanical properties in a load-bearing model on rabbits"],"prefix":"10.1177","volume":"30","author":[{"given":"Andreas","family":"Fottner","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Campus Gro\u00dfhadern, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold","family":"Nies","sequence":"additional","affiliation":[{"name":"InnoTERE GmbH, Pharmapark Radebeul, Radebeul, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Kitanovic","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Campus Gro\u00dfhadern, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnd","family":"Steinbr\u00fcck","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Campus Gro\u00dfhadern, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Hausdorf","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Campus Gro\u00dfhadern, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Mayer-Wagner","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Campus Gro\u00dfhadern, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Pohl","sequence":"additional","affiliation":[{"name":"Walter Brendel Centre of Experimental Medicine, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volkmar","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Campus Gro\u00dfhadern, Munich, 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