{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:07:00Z","timestamp":1777788420694,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:00:00Z","timestamp":1435276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate in\u00a0vitro cytotoxicity\/biocompatibility as well as in\u00a0vivo tolerability of the novel polysaccharide 4DryField\u00ae PH, certified for haemostasis and adhesion prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In\u00a0vitro cytotoxicity\/viability testing according to ISO EN 10,993 using murine and human tumour cell lines incubated with 4DryField\u00ae PH (PlantTec Medical GmbH). Using a rat model the impact of 4DryField\u00ae PH on animals viability and in\u00a0vivo effects were macro- and micropathologically assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In\u00a0vitro testing revealed no cytotoxic effect of 4DryField\u00ae PH nor enhancement of viability to tumour cell lines. In\u00a0vivo viability of rats was unimpaired by 4DryField\u00ae PH. Bodyweight loss in animals with abdominal injury plus treatment with 4DryField\u00ae PH was in the range of controls and less than in injured rats without treatment. At day 7 after surgery no formation of adhesions, neither macroscopic nor histological remnants nor signs of foreign body reaction were present in animals without injury. In animals with peritoneal injury and 4DryField\u00ae PH application, histopathological observation revealed minor residuals of polysaccharide in the depth of wound cavity embedded in a thickened subperitoneal layer; however, with a suggested intact neoperitoneum. The presence of mononuclear cells surrounding polysaccharide particles in varying states of degradation was observable as well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>4DryField\u00ae PH is not cytotoxic and does not enhance viability of tumour cell lines. High dose of 4DryField\u00ae PH of 1.09\u2009g\/kg bodyweight is well tolerated and reduces weight loss in animals with peritoneal injury. The biocompatibility of 4DryField\u00ae PH can be rated as being excellent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0885328215592257","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T22:26:04Z","timestamp":1435357564000},"page":"463-471","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of the biological tolerability of the starch-based medical device 4DryField\u00ae PH\n                    <i>in\u00a0vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    a rat model"],"prefix":"10.1177","volume":"30","author":[{"given":"Daniel","family":"Poehnert","sequence":"first","affiliation":[{"name":"Department of General, Abdominal and Transplantation Surgery, Hannover Medical School, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hannover Medical School, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia","family":"Maegel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hannover Medical School, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Sambale","sequence":"additional","affiliation":[{"name":"Institute of Technical Chemistry, Leibniz University Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonina","family":"Lavrentieva","sequence":"additional","affiliation":[{"name":"Institute of Technical Chemistry, Leibniz University Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Heinrich","family":"Kreipe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hannover Medical School, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Klempnauer","sequence":"additional","affiliation":[{"name":"Department of General, Abdominal and Transplantation Surgery, Hannover Medical School, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Winny","sequence":"additional","affiliation":[{"name":"Department of General, Abdominal and Transplantation Surgery, Hannover Medical School, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,26]]},"reference":[{"key":"bibr1-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6357"},{"key":"bibr2-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1016\/j.jen.2004.01.004"},{"key":"bibr3-0885328215592257","unstructured":"Hanke AA, Fl\u00f6ricke F, Sieg L, et\u00a0al. 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Marked reduction of peritoneal adhesion formation in rat model of cecal abrasion by a novel anti-adhesive agent, 4DryField\u00ae PH. In: J\u00e4hne J (ed.)\n                      131st Congress of the German society for surgery\n                      , Berlin, Germany, 2014, pp. 371\u2013413.","DOI":"10.1007\/s00423-014-1175-9"},{"key":"bibr11-0885328215592257","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.8870"},{"key":"bibr12-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200210000-00015"},{"key":"bibr13-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.01.032"},{"key":"bibr14-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(02)00328-7"},{"key":"bibr15-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1007\/BF02388149"},{"key":"bibr16-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1080\/02688699646989"},{"key":"bibr17-0885328215592257","first-page":"369","volume":"63","author":"Ereth MH","year":"2008","journal-title":"Neurosurgery"},{"key":"bibr18-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-004-0727-z"},{"key":"bibr19-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1080\/089419399272656"},{"key":"bibr20-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-009-3769-2"},{"key":"bibr21-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1179\/016164101101198794"},{"key":"bibr22-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2004.06.006"},{"key":"bibr23-0885328215592257","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.6.547"}],"container-title":["Journal of Biomaterials Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885328215592257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0885328215592257","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885328215592257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:53:36Z","timestamp":1777492416000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0885328215592257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,26]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1177\/0885328215592257"],"URL":"https:\/\/doi.org\/10.1177\/0885328215592257","relation":{},"ISSN":["0885-3282","1530-8022"],"issn-type":[{"value":"0885-3282","type":"print"},{"value":"1530-8022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,26]]}}}