{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:07:38Z","timestamp":1777788458993,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T00:00:00Z","timestamp":1441756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Total auricular reconstruction is still a challenge, and autologous cartilage transplant is the main therapy so far. Tissue engineering provides a promising method for auricular cartilage reconstruction. However, although degradable framework demonstrated excellent initial cosmetic details, it is difficult to maintain the auricular contour over time and the metabolites tended to be harmful to human body. In this study, biocompatible and safe nondegradable elastic polyurethane was used to make porous scaffold in specific details by rapid prototyping technology. Platelet-rich plasma contains fibrin and abundant autologous growth factors, which was used as cell carriers for in\u00a0vitro expanded cells. When crosslinking polyurethane framework, platelet-rich plasma and cells together, we successfully made polyurethane\/platelet-rich plasma\/cell composites, and implanted them into dorsal subcutaneous space of nude mice. The results showed that this method resulted in more even cell distribution and higher cell density, promoted chondrocyte proliferation, induced higher level expressions of aggrecan and type II collagen gene, increased content of newly developed glycosaminoglycans, and produced high-quality cartilaginous tissue. This kind of cartilage tissue engineering approach may be a potential promising alternative for external ear reconstruction.<\/jats:p>","DOI":"10.1177\/0885328215604818","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T19:58:57Z","timestamp":1441915137000},"page":"889-899","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Platelet-rich plasma gel composited with nondegradable porous polyurethane scaffolds as a potential auricular cartilage alternative"],"prefix":"10.1177","volume":"30","author":[{"given":"Zhongshan","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Military Stomatology, Department of Prosthetic Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Qin","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology, Department of Prosthetic Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology, Department of Prosthetic Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,9,9]]},"reference":[{"key":"bibr1-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0216"},{"key":"bibr2-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199001000-00006"},{"key":"bibr3-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00501-5"},{"key":"bibr4-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00340-5"},{"key":"bibr5-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0393"},{"key":"bibr6-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199708000-00001"},{"key":"bibr7-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1007\/s001060050067"},{"key":"bibr8-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-008-3037-8"},{"key":"bibr9-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.1985"},{"key":"bibr10-0885328215604818","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1016\/j.biomaterials.2005.06.018","volume":"27","author":"Williamson MR","year":"2006","journal-title":"Biomaterials"},{"key":"bibr11-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00462-9"},{"key":"bibr12-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1016\/S1007-0214(09)70059-8"},{"key":"bibr13-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32385"},{"key":"bibr14-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(00)90058-2"},{"key":"bibr15-0885328215604818","author":"Lan L","year":"2015","journal-title":"Wound Repair Regen"},{"key":"bibr16-0885328215604818","first-page":"e38","volume":"11","author":"Carter MJ","year":"2011","journal-title":"Eplasty"},{"key":"bibr17-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.03.079"},{"key":"bibr18-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.07.048"},{"key":"bibr19-0885328215604818","first-page":"819, 830","volume":"7","author":"Zhu J","year":"2013","journal-title":"J Tissue Eng & Regen Med"},{"key":"bibr20-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.11.044"},{"key":"bibr21-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1002\/term.496"},{"key":"bibr22-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1993.1197"},{"key":"bibr23-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.06.058"},{"key":"bibr24-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10015"},{"key":"bibr25-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0358"},{"key":"bibr26-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10150"},{"key":"bibr27-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.021"},{"key":"bibr28-0885328215604818","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1051\/ject\/200638174","volume":"38","author":"Everts PA","year":"2006","journal-title":"J Extra Corpor Technol"},{"key":"bibr29-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2014.01.018"},{"key":"bibr30-0885328215604818","first-page":"180","volume":"2","author":"Drengk A","year":"2007","journal-title":"J Stem Cells Regen Med"},{"key":"bibr31-0885328215604818","first-page":"257","volume":"7","author":"Xu FT","year":"2015","journal-title":"Am J Transl Res"},{"key":"bibr32-0885328215604818","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.te24"},{"key":"bibr33-0885328215604818","first-page":"3","volume":"16","author":"Jones JL","year":"1995","journal-title":"Endocr Rev"},{"key":"bibr34-0885328215604818","doi-asserted-by":"publisher","DOI":"10.1186\/ar4493"},{"key":"bibr35-0885328215604818","author":"Mcclure MJ","year":"2013","journal-title":"J Tissue Eng Regen Med"}],"container-title":["Journal of Biomaterials Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885328215604818","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0885328215604818","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885328215604818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:53:41Z","timestamp":1777492421000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0885328215604818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,9]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1177\/0885328215604818"],"URL":"https:\/\/doi.org\/10.1177\/0885328215604818","relation":{},"ISSN":["0885-3282","1530-8022"],"issn-type":[{"value":"0885-3282","type":"print"},{"value":"1530-8022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,9]]}}}