{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:22:18Z","timestamp":1789593738871,"version":"build-2803163510"},"reference-count":44,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2015,10,18]],"date-time":"2015-10-18T00:00:00Z","timestamp":1445126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Previous studies have demonstrated the effect of human parathyroid hormone (1\u201334) (PTH) or strontium-doped hydroxyapatite coating (Sr-HA) on osteoporotic bone implantation. However, reports about effects of PTH plus Sr-HA on bone osseointegration of titanium implants in a state of osteoporosis were limited. This study was designed to investigate the effects of intermittent administration of human parathyroid hormone (1\u201334) on strontium-doped hydroxyapatite coating (Sr-HA) implant fixation in ovariectomized (OVX) rats. Twelve weeks after bilateral ovariectomy, all animals were randomly divided into four groups including control group, Sr group, PTH group and PTH+Sr group. Forty OVX rats accepted implant insertion in the distal femurs, control group, and PTH group with HA implants and the Sr group and PTH+Sr group with Sr-HA implants. Animals from PTH group and PTH+Sr group then randomly received PTH (60\u2009\u00b5g\/kg, 3 times a week) until death at 12 weeks. After 12-week healing period, implants from group PTH+Sr revealed improved osseointegration compared with other treatment groups, which is manifested by the exceeding increase of bone area ratio and bone-to-implant contact, the trabecular microarchitecture and the maximal push-out force displayed by tests like histomorphometry, micro-CT, and biomechanics evaluation. These results demonstrated that PTH+ Sr-HA coatings could enhance implant osseointegration in OVX rats, and suggested the feasibility of using this method to improve implant fixation in osteoporotic bone.<\/jats:p>","DOI":"10.1177\/0885328215610898","type":"journal-article","created":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T19:57:50Z","timestamp":1445284670000},"page":"952-960","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["Intermittent administration of human parathyroid hormone (1\u201334) increases fixation of strontium-doped hydroxyapatite coating titanium implants via electrochemical deposition in ovariectomized rat femur"],"prefix":"10.1177","volume":"30","author":[{"given":"Zhou-Shan","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Shu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Endocrine & Metabolic Diseases Unit, Affiliated Hospital of Guizhou Medcial University, Guizhou, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Qiang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-kai","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Xun","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Wenzhou Central Hospital, Wenzhou, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cui","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Orthopedics Hospital, Sichuan, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,10,18]]},"reference":[{"key":"bibr1-0885328215610898","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.00155"},{"key":"bibr2-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2007.06.018"},{"key":"bibr3-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32000"},{"key":"bibr4-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1080\/00016470310013851"},{"key":"bibr5-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1054\/arth.2002.29395"},{"key":"bibr6-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.81B4.9138"},{"key":"bibr7-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(94)90189-9"},{"key":"bibr8-0885328215610898","first-page":"28","volume":"17","author":"Fini M","year":"2001","journal-title":"Int J Oral Maxillofac Implants"},{"key":"bibr9-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00213-7"},{"key":"bibr10-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90218-E"},{"key":"bibr11-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0006"},{"key":"bibr12-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-014-0152-z"},{"key":"bibr13-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21050"},{"key":"bibr14-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070607"},{"key":"bibr15-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000229522.89546.7b"},{"key":"bibr16-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070321"},{"key":"bibr17-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.08.043"},{"key":"bibr18-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.04.002"},{"key":"bibr19-0885328215610898","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15069952"},{"key":"bibr20-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1100381"},{"key":"bibr21-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.07.112"},{"key":"bibr22-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.07.042"},{"key":"bibr23-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1177\/0885328215592854"},{"key":"bibr24-0885328215610898","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.70.7.585"},{"key":"bibr25-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2258-5"},{"key":"bibr26-0885328215610898","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00344"},{"key":"bibr27-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070901"},{"key":"bibr28-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.07.112"},{"key":"bibr29-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092360303"},{"key":"bibr30-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-008-1275-x"},{"key":"bibr31-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-1031-x"},{"key":"bibr32-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1700529"},{"key":"bibr33-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070047"},{"key":"bibr34-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.03.017"},{"key":"bibr35-0885328215610898","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.2038"},{"key":"bibr36-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0815-8"},{"key":"bibr37-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.071012"},{"key":"bibr38-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1159\/000327950"},{"key":"bibr39-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.01.120"},{"key":"bibr40-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-8-16"},{"key":"bibr41-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2009.0504"},{"key":"bibr42-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6610"},{"key":"bibr43-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1126\/science.305.5689.1420"},{"key":"bibr44-0885328215610898","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-011-4264-0"}],"container-title":["Journal of Biomaterials Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885328215610898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0885328215610898","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885328215610898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:53:42Z","timestamp":1777492422000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0885328215610898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,18]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1177\/0885328215610898"],"URL":"https:\/\/doi.org\/10.1177\/0885328215610898","relation":{},"ISSN":["0885-3282","1530-8022"],"issn-type":[{"value":"0885-3282","type":"print"},{"value":"1530-8022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,18]]}}}