{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:56:02Z","timestamp":1791316562446,"version":"4.3.1"},"reference-count":42,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,9,25]],"date-time":"2016-09-25T00:00:00Z","timestamp":1474761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>\n                    A functionally modified peptide-conjugated hydrogel system was fabricated with oxidized alginate\/gelatin loaded with biphasic calcium phosphate to improve its biocompatibility and functionality. Sodium alginate was treated by controlled oxidation to transform the cis-diol group into an aldehyde group in a controlled manner, which was then conjugated to the amine terminus of glycine\u2013arginine\u2013glycine\u2013aspartic. Oxidized alginate glycine\u2013arginine\u2013glycine\u2013aspartic was then combined with gelatin-loaded biphasic calcium phosphate to form a hydrogel of composite oxidized alginate\/gelatin\/biphasic calcium phosphate that displayed enhanced human adipose stem cell adhesion, spreading and differentiation.\n                    <jats:sup>1<\/jats:sup>\n                    H nuclear magnetic resonance and electron spectroscopy for chemical analysis confirmed that the glycine\u2013arginine\u2013glycine\u2013aspartic was successfully grafted to the oxidized alginate. Co-delivery of glycine\u2013arginine\u2013glycine\u2013aspartic and human adipose stem cell in a hydrogel matrix was studied with the results indicating that hydrogel incorporated modified with glycine\u2013arginine\u2013glycine\u2013aspartic and seeded with human adipose stem cell enhanced osteogenesis in\u00a0vitro and bone formation in\u00a0vivo.\n                  <\/jats:p>","DOI":"10.1177\/0885328216667633","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T20:08:36Z","timestamp":1473278916000},"page":"661-673","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Augmenting in\u00a0vitro osteogenesis of a glycine\u2013arginine\u2013glycine\u2013aspartic-conjugated oxidized alginate\u2013gelatin\u2013biphasic calcium phosphate hydrogel composite and in\u00a0vivo bone biogenesis through stem cell delivery"],"prefix":"10.1177","volume":"31","author":[{"given":"Nguyen TB","family":"Linh","sequence":"first","affiliation":[{"name":"Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan, Korea"},{"name":"Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kallyanashis","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boram","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byong-Taek","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan, Korea"},{"name":"Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,9,25]]},"reference":[{"key":"bibr1-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201400760"},{"key":"bibr2-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.01.027"},{"key":"bibr3-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0313"},{"key":"bibr4-0885328216667633","first-page":"923","volume":"3","author":"Ivkovic A","year":"2010","journal-title":"Front Biosci"},{"key":"bibr5-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1002\/term.1497"},{"key":"bibr6-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201300562"},{"key":"bibr7-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1007\/s13233-011-0309-y"},{"key":"bibr8-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.06.010"},{"key":"bibr9-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.01.011"},{"key":"bibr10-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1021\/bm300733n"},{"key":"bibr11-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0250"},{"key":"bibr12-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0386"},{"key":"bibr13-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.03.018"},{"key":"bibr14-0885328216667633","doi-asserted-by":"publisher","DOI":"10.4103\/2321-3868.143616"},{"key":"bibr15-0885328216667633","first-page":"89","volume":"1","author":"Babavalian H","year":"2014","journal-title":"J Appl Biotechnol Rep"},{"key":"bibr16-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32287"},{"key":"bibr17-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00340-5"},{"key":"bibr18-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1021\/bm800286v"},{"key":"bibr19-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00295-3"},{"key":"bibr20-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-009-3694-4"},{"key":"bibr21-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.11.022"},{"key":"bibr22-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2013.04.028"},{"key":"bibr23-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1177\/0885328211404265"},{"key":"bibr24-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1177\/0883911515569008"},{"key":"bibr25-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2007.02.009"},{"key":"bibr26-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(03)58005-X"},{"key":"bibr27-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2001.025008617.x"},{"key":"bibr28-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0306"},{"key":"bibr29-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00176-X"},{"key":"bibr30-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00343-0"},{"key":"bibr31-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)61348-5"},{"key":"bibr32-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1039\/c3tb21509a"},{"key":"bibr33-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800111501"},{"key":"bibr34-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1159\/000324892"},{"key":"bibr35-0885328216667633","doi-asserted-by":"publisher","DOI":"10.3109\/14653241003649528"},{"key":"bibr36-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34983"},{"key":"bibr37-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041520305"},{"key":"bibr38-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1002\/term.287"},{"key":"bibr39-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1002\/term.388"},{"key":"bibr40-0885328216667633","doi-asserted-by":"crossref","unstructured":"Heal HADSC, Levi B, James AW, et\u00a0al. Human adipose derived stromal cells heal critical size mouse calvarial defects.\n                      PLoS One\n                      2010; 5(6): e11177.","DOI":"10.1371\/journal.pone.0011177"},{"key":"bibr41-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-007-0351-1"},{"key":"bibr42-0885328216667633","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e31825f70f5"}],"container-title":["Journal of Biomaterials Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885328216667633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0885328216667633","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0885328216667633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:54:08Z","timestamp":1777492448000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0885328216667633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,25]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1177\/0885328216667633"],"URL":"https:\/\/doi.org\/10.1177\/0885328216667633","relation":{},"ISSN":["0885-3282","1530-8022"],"issn-type":[{"value":"0885-3282","type":"print"},{"value":"1530-8022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,25]]}}}