{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:12:03Z","timestamp":1777788723441,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>\n                    Iron deficiency remains a public health problem around the world due to low iron intake and\/or bioavailability. FeSO\n                    <jats:sub>4<\/jats:sub>\n                    , ferrous succinate, and ferrous glycinate chelate are rich in iron but have poor bioavailability. To solve the problem of iron deficiency, following previous research studies, a thiolated human-like collagen-ironcomplex supplement with a high iron content was prepared in an anaerobic workstation. In addition, cell viability tests were evaluated after conducting an MTT assay, and a quantitative analysis of the thiolated human-like collagen-iron digesta samples was performed using the SDS-PAGE method coupled with gel filtration chromatography. The iron bioavailability was assessed using Caco-2 cell monolayers and iron-deficiency anemia mice models. The results showed that (1) one mole of thiolated human-like collagen-iron possessed approximately 35.34 moles of iron; (2) thiolated human-like collagen-iron did not exhibit cytotoxity and (3) thiolated human-like collagen- iron digesta samples had higher bioavailability than other iron supplements, including FeSO\n                    <jats:sub>4<\/jats:sub>\n                    , ferrous succinate, ferrous glycine chelate and thiolated human-like collagen-Fe iron. Finally, the iron bioavailability was significantly enhanced by vitamin C. These results indicated that thiolated human-like collagen-iron is a promising iron supplement for use in the future.\n                  <\/jats:p>","DOI":"10.1177\/0885328217708638","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T05:59:20Z","timestamp":1494568760000},"page":"82-92","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Higher iron bioavailability of a human-like collagen iron complex"],"prefix":"10.1177","volume":"32","author":[{"given":"Chenhui","family":"Zhu","sequence":"first","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, China"},{"name":"Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, China"},{"name":"Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daidi","family":"Fan","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, China"},{"name":"Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Wang","sequence":"additional","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an, China"},{"name":"Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Shaanxi Xueqian Normal University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,5,11]]},"reference":[{"key":"bibr1-0885328217708638","first-page":"907","volume":"387","author":"Lopez A","year":"2016","journal-title":"Br Med J"},{"key":"bibr2-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24201"},{"key":"bibr3-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-014-1643-9"},{"key":"bibr4-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.2.267"},{"key":"bibr5-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0572"},{"key":"bibr6-0885328217708638","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2932"},{"key":"bibr7-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117383"},{"key":"bibr8-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02652.x"},{"key":"bibr9-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.74.6.435"},{"key":"bibr10-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2016.06.011"},{"key":"bibr11-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2005.10.010"},{"key":"bibr12-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2009.08.008"},{"key":"bibr13-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1016\/S1004-9541(08)60334-1"},{"key":"bibr14-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrysgro.2006.03.006"},{"key":"bibr15-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1177\/0885328215621250"},{"key":"bibr16-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.05.038"},{"key":"bibr17-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1042\/BA20100081"},{"key":"bibr18-0885328217708638","doi-asserted-by":"publisher","DOI":"10.1021\/jf9033199"},{"key":"bibr19-0885328217708638","doi-asserted-by":"crossref","unstructured":"Production of dialysable iron by in\u00a0vitro digestion of chicken muscle protein fractions: the size of the dialysable iron.\n                      J Sci Food Agr\n                      2010; 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