{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:17:38Z","timestamp":1790018258030,"version":"4.0.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T00:00:00Z","timestamp":1521417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the natural science foundation for education department of Anhui Province","award":["KJ2017A266"],"award-info":[{"award-number":["KJ2017A266"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    The objective of the present study was to incorporate strontium into calcium phosphate cement combined with a lower single-dose local administration of bone morphogenetic protein-2 to enhance its in vivo biodegradation and bone tissue growth. After the creation of a rodent critical-sized femoral metaphyseal bone defect, strontium-modified calcium phosphate cement was prepared by mixing sieved granules of calcium phosphate cement and 5% SrCO\n                    <jats:sub>3<\/jats:sub>\n                    for medical use, and then strontium-modified calcium phosphate cement with dripped bone morphogenetic protein-2 solution (5 \u00b5g) was implanted into the defect of OVX rats until death at eight weeks. The defected area in distal femurs of rats was harvested for evaluation by histology, micro-CT, and biomechanics. The results of our study show that a lower single-dose local administration of bone morphogenetic protein-2 combined local usage of strontium-modified calcium phosphate cement can increase the healing of defects in OVX rats. Furthermore, treatments with single-dose local administration of bone morphogenetic protein-2 and strontium-modified calcium phosphate cement showed a stronger effect on accelerating the local bone formation than calcium phosphate cement and strontium-modified calcium phosphate cement used alone. The results from our study demonstrate that combination of a lower single-dose local administration of bone morphogenetic protein-2 and strontium-modified calcium phosphate cement had an additive effect on local bone formation in osteoporosis rats.\n                  <\/jats:p>","DOI":"10.1177\/0885328218765847","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T01:10:58Z","timestamp":1521508258000},"page":"3-10","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-9289","authenticated-orcid":false,"given":"Zhoushan","family":"Tao","sequence":"first","affiliation":[{"name":"Wannan Medical College First Affiliated Hospital, Yijishan Hospital, Traumatology Orthopedics, Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanshu","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Wannan Medical College First Affiliated Hospital, Yijishan Hospital, Traumatology Orthopedics, Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjin","family":"Wu","sequence":"additional","affiliation":[{"name":"Wannan Medical College First Affiliated Hospital, Yijishan Hospital, Traumatology Orthopedics, Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhujun","family":"Xu","sequence":"additional","affiliation":[{"name":"Wannan Medical College First Affiliated Hospital, Yijishan Hospital, Traumatology Orthopedics, Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Wannan Medical College First Affiliated Hospital, Yijishan Hospital, Traumatology Orthopedics, Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabing","family":"Xie","sequence":"additional","affiliation":[{"name":"Wannan Medical College First Affiliated Hospital, Yijishan Hospital, Traumatology Orthopedics, Wuhu, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"key":"bibr1-0885328218765847","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-011-0060-1"},{"key":"bibr2-0885328218765847","doi-asserted-by":"crossref","unstructured":"NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. 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A comparative study of strontium-substituted hydroxyapatite coating on implant's osseointegration for osteopenic rats.\n                      Med Biol Eng Comput\n                      2016; 54: 1959\u20131968.","DOI":"10.1007\/s11517-016-1494-9"},{"key":"bibr19-0885328218765847","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2015.09.004"},{"key":"bibr20-0885328218765847","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.06.021"},{"key":"bibr21-0885328218765847","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.06.029"},{"key":"bibr22-0885328218765847","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-015-5650-9"},{"key":"bibr23-0885328218765847","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-013-0496-z"},{"key":"bibr24-0885328218765847","doi-asserted-by":"publisher","DOI":"10.1177\/0885328215592854"},{"key":"bibr25-0885328218765847","doi-asserted-by":"crossref","unstructured":"Tao ZS, Zhou WS, Wu XJ, et\u00a0al. Single-dose local administration of parathyroid hormone (1-34, PTH) with beta-tricalcium phosphate\/collagen (beta-TCP\/COL) enhances bone defect healing in ovariectomized rats.\n                      J Bone Miner Metab\n                      . Epub ahead of print 1 February 2018. 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