{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:15:08Z","timestamp":1777788908619,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Sylvan Foundation"},{"DOI":"10.13039\/501100005294","name":"Sigge Perssons & Alice Nybergs stiftelse (Gothenburg Dental Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005294","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Adlerbert Research Foundation"},{"name":"The Hjalmar Svensson Research Foundation"},{"name":"The Wilhelm and Martina Lundgren Science Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the cytokine expression profiles of blood cells exposed to polyetheretherketone and titanium-6 aluminum-4 vanadium materials in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Coin-shaped samples composed of titanium-6 aluminum-4 vanadium, polyetheretherketone, and blasted polyetheretherketone were manufactured. The surfaces of the coins were characterized using optical interferometry, scanning electron microscopy, and contact angle measurements. Peripheral blood mononuclear cells collected from 10 blood donors were cultured for one, three, and six days in the presence or absence of the coins, and then assayed for cytokine production. Quantification of the peripheral blood mononuclear cells attached to the coins was performed using confocal microscopy after immunofluorescence staining.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The machined titanium-6 aluminum-4 vanadium coins had a smoother surface topography compared to the machined polyetheretherketone and blasted polyetheretherketone. The highest mean contact angle was noted for the blasted polyetheretherketone, followed by the machined polyetheretherketone and titanium-6 aluminum-4 vanadium. The peripheral blood mononuclear cells produced significantly more proinflammatory cytokines when exposed to the polyetheretherketone surface compared to the titanium-6 aluminum-4 vanadium surface, while the blasted polyetheretherketone induced the highest level of proinflammatory cytokine release from the peripheral blood mononuclear cells. Significantly more cells attached to both polyetheretherketone surfaces, as compared to the titanium-6 aluminum-4 vanadium surface.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Polyetheretherketone induces a stronger inflammatory response from peripheral blood mononuclear cells than does titanium-6 aluminum-4 vanadium. Surface topography has an impact on cytokine release from peripheral blood mononuclear cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0885328218786005","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:46:07Z","timestamp":1531442767000},"page":"245-258","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Inflammatory cytokine release from human peripheral blood mononuclear cells exposed to polyetheretherketone and titanium-6 aluminum-4 vanadium in vitro"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7786-8113","authenticated-orcid":false,"given":"Sargon","family":"Barkarmo","sequence":"first","affiliation":[{"name":"The Sahlgrenska Academy, Institute of Odontology, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Karin","family":"\u00d6stberg","sequence":"additional","affiliation":[{"name":"The Sahlgrenska Academy, Institute of Odontology, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina Birgitta","family":"Johansson","sequence":"additional","affiliation":[{"name":"The Sahlgrenska Academy, Institute of Odontology, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Franco-Tabares","sequence":"additional","affiliation":[{"name":"The Sahlgrenska Academy, Institute of Odontology, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra Hammarstr\u00f6m","family":"Johansson","sequence":"additional","affiliation":[{"name":"The Sahlgrenska Academy, Institute of Odontology, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Dahlgren","sequence":"additional","affiliation":[{"name":"The Sahlgrenska Academy, Institute of Odontology, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Stenport","sequence":"additional","affiliation":[{"name":"The Sahlgrenska Academy, Institute of Odontology, G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7,12]]},"reference":[{"key":"bibr1-0885328218786005","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.07.013"},{"key":"bibr2-0885328218786005","volume-title":"Titanium in medicine: material science, surface science, engineering, biological responses and medical applications","author":"Brunette DM","year":"2012"},{"key":"bibr3-0885328218786005","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-5093(97)00806-X"},{"key":"bibr4-0885328218786005","doi-asserted-by":"publisher","DOI":"10.3109\/17453678108991776"},{"key":"bibr5-0885328218786005","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.05.078"},{"key":"bibr6-0885328218786005","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"bibr7-0885328218786005","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31221"},{"key":"bibr8-0885328218786005","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000225430.42531.c2"},{"key":"bibr9-0885328218786005","first-page":"1487","volume":"147","author":"McNally AK","year":"1995","journal-title":"Am J Pathol"},{"key":"bibr10-0885328218786005","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.03.047"},{"key":"bibr11-0885328218786005","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-014-3466-9"},{"key":"bibr12-0885328218786005","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.07.011"},{"key":"bibr13-0885328218786005","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000000778"},{"key":"bibr14-0885328218786005","doi-asserted-by":"crossref","unstructured":"Rahmat Sam MF, Curran JM and Hunt JA. 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