{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:38:11Z","timestamp":1777786691674,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["Basic Science Research Program\/2017R1A2B3011121"],"award-info":[{"award-number":["Basic Science Research Program\/2017R1A2B3011121"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["Bio & Medical Technology Development Program\/2014M"],"award-info":[{"award-number":["Bio & Medical Technology Development Program\/2014M"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["Cell Regeneration Program\/2012M2A9C6049717"],"award-info":[{"award-number":["Cell Regeneration Program\/2012M2A9C6049717"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>\n                    Polymer-based drug-eluting stents (DESs) represented attractive application for the treatment of cardiovascular diseases; however, polymer coating has caused serious adverse responses to tissues such as chronic inflammation due to acidic by-products. Therefore, polymer-free DESs have recently emerged as promising candidates for the treatment; however, burst release of drug(s) from the surface limited its applications. In this study, we focused on delivery of therapeutic drug from polymer-free (or -less) DESs through surface modification using cobalt oxide nanowires (Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    NWs) to improve and control the drug release. The results demonstrated that Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    NWs could be simply fabricated on cobalt\u2013chromium substrate by ammonia-evaporation-induced method. The Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    NWs were uniformly arrayed with diameters of 50\u2013100 nm and lengths of 10 \u00b5m. It was found that Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    NWs were comparatively stable without any delamination or change of the morphology under in vitro long-term stability using circulating system. Sirolimus was used as a model drug for studying in vitro release behavior under physiological conditions. The sirolimus release behavior from flat cobalt\u2013chromium showed an initial burst (over 90%) after one day. On the other hand, Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    NWs presented a sustained sirolimus release rate for up to seven days. Similarly, the polymer-less specimens on Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    NWs substrates sustained sirolimus release for a longer-period of time when compared to flat Co\u2013Cr substrates. In summary, the current approach of using Co\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    NWs-based substrates might have a great potential to sustain drug release for drug-eluting implants and medical devices including stents.\n                  <\/jats:p>","DOI":"10.1177\/0885328218792141","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T01:14:38Z","timestamp":1537233278000},"page":"352-362","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Sustained drug release using cobalt oxide nanowires for the preparation of polymer-free drug-eluting stents"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9015-9071","authenticated-orcid":false,"given":"Tarek M","family":"Bedair","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, CHA University, Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi, Republic of Korea"},{"name":"Chemistry Department, Faculty of Science, Minia University, El-Minia, Egypt"},{"name":"Center for Biomaterials, Korea Institute of Science and Technology, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il Jae","family":"Min","sequence":"additional","affiliation":[{"name":"Center for Biomaterials, Korea Institute of Science and Technology, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wooram","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Ki","family":"Joung","sequence":"additional","affiliation":[{"name":"Center for Biomaterials, Korea Institute of Science and Technology, Seoul, Republic of Korea"},{"name":"Department of Biomedical Engineering, Korea University of Science and Technology, Daejeon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-7883","authenticated-orcid":false,"given":"Dong Keun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, CHA University, Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi, Republic of 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