{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:36:10Z","timestamp":1780320970481,"version":"3.54.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31671214"],"award-info":[{"award-number":["31671214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014442","name":"Shandong Talents Team Cultivation Plan of University Preponderant Discipline","doi-asserted-by":"crossref","award":["10027"],"award-info":[{"award-number":["10027"]}],"id":[{"id":"10.13039\/100014442","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Young Taishan Scholars Program","award":["tsqn20161037"],"award-info":[{"award-number":["tsqn20161037"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>\n                    Although curcumin possesses anti-atherogenic and anti-inflammatory properties, its application is limited because of its low aqueous solubility and poor oral bioavailability. Recently, our group synthesized a novel linear-dendrimer methoxy-poly (ethylene glycol)-b-poly(\u03b5-caprolactone) copolymer nanoparticle loading curcumin (Cur-NPs) which could improve solubility and release property of curcumin. In the present study, we further evaluated its anti-atherosclerotic effect in apolipoprotein E\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Our results demonstrated that the Cur-NPs significantly decreased atherosclerotic lesion areas and were more effective in stabilizing vulnerable plaques compared with free curcumin. The anti-atherosclerotic mechanisms of Cur-NPs include decreasing the number of introplaque microvessels, inhibiting the matrix metalloproteinase 2 and 9 activity, reducing the inflammatory response and regulating lipoprotein cholesterol metabolism more effectively compared with free curcumin. Furthermore, Cur-NPs could increase the amount of curcumin in the thoracic aorta and no significant toxicity was observed in the blood biochemical parameters in Cur-NPs-treated groups. Overall, our findings suggested that Cur-NPs could be a stabilized aqueous formulation for application with improved curcumin activity, which could be a potential treatment strategy for arteriosclerosis in the future.\n                  <\/jats:p>","DOI":"10.1177\/0885328218815328","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T01:30:12Z","timestamp":1544664612000},"page":"946-954","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["A novel curcumin-loaded nanoparticle restricts atherosclerosis development and promotes plaques stability in apolipoprotein E deficient mice"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-9916","authenticated-orcid":false,"given":"Ning","family":"Meng","sequence":"first","affiliation":[{"name":"School of Biological Science and Technology, University of Jinan, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology, University of Jinan, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiefeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central Hospital of Taian, Taian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Mu","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology, University of Jinan, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimei","family":"Song","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology, University of Jinan, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runliang","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology, University of Jinan, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Technology, University of Jinan, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/463797"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100440"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2014.09.001"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/BME-161610"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100818"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b04260"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12611"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19164"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2017.03.005"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.901436"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2929-0_5"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.04.062"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.07.022"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389201011208062435"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.01.007"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187767"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2016.01.005"},{"key":"e_1_3_5_20_2","doi-asserted-by":"crossref","unstructured":"Miteva K Madonna R De Caterina R et\u00a0al. Innate and adaptive immunity in atherosclerosis. 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