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Previously,\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    evaluation proved the detergent\u2013enzymatic method effectively removed stromal epithelial cells, and the number of nuclei was reduced significantly (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The content of type II collagen was not statistically reduced (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05). Plasmids with green fluorescence protein were transfected into 293T cells, and these cells subsequently synthesized lentivirus with green fluorescence protein that could infect other cells. After\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    experiments, macroscopic specimen observation and hematoxylin and eosin staining comparison showed that the genipin cross-linked decellularized scaffold had low immunological rejection. Blood routine proved the progenitor cells (such as mononuclear cells) can be mobilized from the bone marrow by the growth factors, to allow their circulation into the peripheral blood. The immunohistochemistry of Type II collagen after surgery showed the expression level of bone marrow mesenchymal stem cells transplantated group was statistically higher than the autologous transplantated group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The fluorescences of Bone marrow mononuclear cells (BMNCs) were traced after the specimens harvested. It successfully demonstrated that the procedures combining stem cells with the genipin cross-linked decellularized scaffold could apply to in situ airway construction. Compared to bone marrow mesenchymal stem cells, BMNCs can also be used to achieve chondrocyte differentiation; this procedure will avoid\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    cell culture, shortening the time and economic costs.\n                  <\/jats:p>","DOI":"10.1177\/0885328219839193","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T11:26:15Z","timestamp":1554981975000},"page":"47-60","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["<i>In vivo<\/i>\n                    transplantation of stem cells with a genipin linked scaffold for tracheal construction"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-7241","authenticated-orcid":false,"given":"Yi","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Clinical medical 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