{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:18:07Z","timestamp":1777789087507,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"crossref","award":["KJ2017A266"],"award-info":[{"award-number":["KJ2017A266"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funding of \"Peak\" Training Program for Scientific Research of Yijishan Hospital, Wannan Medical College","award":["GF2019G04"],"award-info":[{"award-number":["GF2019G04"]}]},{"name":"Funding of \"Peak\" Training Program for Scientific Research of Yijishan Hospital, Wannan Medical College","award":["GF2019T02"],"award-info":[{"award-number":["GF2019T02"]}]},{"name":"Funding of \"Peak\" Training Program for Scientific Research of Yijishan Hospital, Wannan Medical College","award":["PF2019005"],"award-info":[{"award-number":["PF2019005"]}]},{"name":"Funding of \"Peak\" Training Program for Scientific Research of Yijishan Hospital, Wannan Medical College","award":["PF2019007"],"award-info":[{"award-number":["PF2019007"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>As hydroxyapatite has good osteoconductive properties, it is used as coating material for the implants in cementless arthroplasty. However, its effect is not sufficient for osteoporotic bone. Silymarin promotes osteoblast proliferation and inhibits osteoclast proliferation, and positively affects bone regeneration. System administration of silymarin increases bone strength and both cancellous and cortical bone mass. The aim of this study was to confirm the effect of the local incorporation silymarin into hydroxyapatite-coated titanium implants in the osteoporotic and normal condition. Twelve-week-old female Sprague-Dawley rats were used for this study. Twelve weeks after bilateral ovariectomy, all animals were randomly divided into three groups: group sham, group ovariectomized and group silymarin, and the rats from ovariectomized and sham received hydroxyapatite implants and animals belong to group silymarin received silymarin-hydroxyapatite implants until death at 12 weeks, respectively. The bilateral femurs of rats were harvested for evaluation. All treatments increased new bone formation around the surface of titanium rods and push-out force other than group ovariectomized. Compared with group ovariectomized, group silymarin showed the strongest effects on new bone formation, biomechanical strength and regulation of osteogenesis and bone resorption-related gene expression, respectively. Additionally, these are significant difference in bone formation, gene expression and push-out force was observed among treatment groups. This finding suggests that local incorporation of silymarin is useful to improve the fixation of hydroxyapatite-coated implants in ovariectomized rats.<\/jats:p>","DOI":"10.1177\/0885328219863290","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T05:18:26Z","timestamp":1564031906000},"page":"664-672","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Local administration with silymarin could increase osseointegration of hydroxyapatite-coated titanium implants in ovariectomized rats"],"prefix":"10.1177","volume":"34","author":[{"given":"Zhou-Shan","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Trauma orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Anhui, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Trauma orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Anhui, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Trauma orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Anhui, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9307-3430","authenticated-orcid":false,"given":"Hong-Guang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Spine Research Center of Wannan Medical College, Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Yijishan hospital of Wannan Medical College. 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