{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:21:51Z","timestamp":1784758911518,"version":"3.55.0"},"reference-count":117,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Key Laboratories of Fine Chemicals and Surfactants in Sichuan Provincial Universities","award":["2020JXY02"],"award-info":[{"award-number":["2020JXY02"]}]},{"name":"The Introduction Program of Scientific Researcher of Sichuan University of Science and Engineering","award":["2020RC40"],"award-info":[{"award-number":["2020RC40"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Spider silk protein has attracted much attention on account of its excellent mechanical properties, biodegradability, and biocompatibility. As the main protein component of spider silk, spidroin plays important role in spider spinning under natural circumstances and biomaterial application in medicine as well. Compare to the native spidroin which has a large molecular weight (&gt;300\u2009kDa) with highly repeat glycine and polyalanine regions, the recombinant spidroin was maintained the core amino motifs and much easier to collect. Here, we reviewed the application of recombinant spider silk protein eADF4(C16), major ampullate spidroin (MaSp), minor ampullate spidroin (MiSp), and the derivatives of recombinant spider silk protein in drug delivery system. Moreover, we also reviewed the application of spider silk protein in the field of alternative materials, repairing materials, wound dressing, surgical sutures along with advances in recombinant spider silk protein.<\/jats:p>","DOI":"10.1177\/08853282211003850","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T02:25:53Z","timestamp":1618453553000},"page":"859-871","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Progress in the application of spider silk protein in medicine"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7506-7056","authenticated-orcid":false,"given":"Yi","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratories of Fine Chemicals and Surfactants in Sichuan Provincial Universities, School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratories of Fine Chemicals and Surfactants in Sichuan Provincial Universities, School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minsi","family":"Meng","sequence":"additional","affiliation":[{"name":"Key Laboratories of Fine Chemicals and Surfactants in Sichuan Provincial Universities, School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zigong Fourth People\u2019s Hospital, Zigong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjian","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Zigong First People\u2019s Hospital, Zigong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"bibr1-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1789"},{"key":"bibr2-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-7021(11)70057-8"},{"key":"bibr3-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/S0141-8130(98)00089-0"},{"key":"bibr4-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2013.09.002"},{"key":"bibr5-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200803341"},{"key":"bibr6-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6090-y"},{"key":"bibr7-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110197"},{"key":"bibr8-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000998"},{"key":"bibr9-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.03.042"},{"key":"bibr10-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.10.048"},{"key":"bibr11-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1038\/nature08936"},{"key":"bibr12-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1038\/nature08962"},{"key":"bibr13-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/bm060120k"},{"key":"bibr14-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.08.020"},{"key":"bibr15-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2019.10.058"},{"key":"bibr16-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201003795"},{"key":"bibr17-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.03.153"},{"key":"bibr18-08853282211003850","doi-asserted-by":"publisher","DOI":"10.3390\/polym12051013"},{"key":"bibr19-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5245.84"},{"key":"bibr20-08853282211003850","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00554"},{"key":"bibr21-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2008.02.006"},{"key":"bibr22-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201900583"},{"key":"bibr23-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201400020"},{"key":"bibr24-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.05.069"},{"key":"bibr25-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1080\/00218464.2011.583588"},{"key":"bibr26-08853282211003850","doi-asserted-by":"crossref","unstructured":"Whittall DR, Baker KV, Breitling R, et\u00a0al. Host Systems for the Production of Recombinant Spider Silk.\n                      Trends Biotechnol\n                      2020. DOI: 10.1016\/j.tibtech.2020.09.007.","DOI":"10.1016\/j.tibtech.2020.09.007"},{"key":"bibr27-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.11.060"},{"key":"bibr28-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/bm050421e"},{"key":"bibr29-08853282211003850","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2017-0276"},{"key":"bibr30-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1039\/C7TB00233E"},{"key":"bibr31-08853282211003850","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S168081"},{"key":"bibr32-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.07.014"},{"key":"bibr33-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/bi048983q"},{"key":"bibr34-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24300"},{"key":"bibr35-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1039\/C4BM00401A"},{"key":"bibr36-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65786-4"},{"key":"bibr37-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.10.013"},{"key":"bibr38-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.043"},{"key":"bibr39-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/term.437"},{"key":"bibr40-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.11.007"},{"key":"bibr41-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201300233"},{"key":"bibr42-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.10.053"},{"key":"bibr43-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA00232K"},{"key":"bibr44-08853282211003850","first-page":"1750","volume":"4","author":"Kumari S","year":"2018","journal-title":"ACS Biomater Sci Eng"},{"key":"bibr45-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.04.008"},{"key":"bibr46-08853282211003850","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.2019.69"},{"key":"bibr47-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201900426"},{"key":"bibr48-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1039\/C6BM00435K"},{"key":"bibr49-08853282211003850","doi-asserted-by":"publisher","DOI":"10.3390\/polym10080915"},{"key":"bibr50-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33322"},{"key":"bibr51-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/bc200170u"},{"key":"bibr52-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/bm101055m"},{"key":"bibr53-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/bm500591p"},{"key":"bibr54-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219790"},{"key":"bibr55-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-020-00609-2"},{"key":"bibr56-08853282211003850","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25030737"},{"key":"bibr57-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021833"},{"key":"bibr58-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2019.103436"},{"key":"bibr59-08853282211003850","first-page":"858","volume":"23","author":"Ruan C-R","year":"2007","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"key":"bibr60-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.12.020"},{"key":"bibr61-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b05853"},{"key":"bibr62-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b00183"},{"key":"bibr63-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/term.2089"},{"key":"bibr64-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00436.x"},{"key":"bibr65-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/906819"},{"key":"bibr66-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016990"},{"key":"bibr67-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2008.00534.x"},{"key":"bibr68-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2018.03.016"},{"key":"bibr69-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.12.001"},{"key":"bibr70-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.02.040"},{"key":"bibr71-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.993"},{"key":"bibr72-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21583"},{"key":"bibr73-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201100249"},{"key":"bibr74-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-326"},{"key":"bibr75-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31825"},{"key":"bibr76-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061100"},{"key":"bibr77-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03034-4"},{"key":"bibr78-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.09.004"},{"key":"bibr79-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b05531"},{"key":"bibr80-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182917677"},{"key":"bibr81-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2017.01.002"},{"key":"bibr82-08853282211003850","volume":"7","author":"Cao H","year":"2017","journal-title":"Sci Rep"},{"key":"bibr83-08853282211003850","doi-asserted-by":"publisher","DOI":"10.3390\/genes10060425"},{"key":"bibr84-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2016.01.006"},{"key":"bibr85-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003366107"},{"key":"bibr86-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b13528"},{"key":"bibr87-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b00980"},{"key":"bibr88-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2014.03.010"},{"key":"bibr89-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.12.027"},{"key":"bibr90-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.06.227"},{"key":"bibr91-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.11.014"},{"key":"bibr92-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw2541"},{"key":"bibr93-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b14793"},{"key":"bibr94-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1088\/2053-1583\/aa7cd3"},{"key":"bibr95-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2020.100045"},{"key":"bibr96-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201604245"},{"key":"bibr97-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c06344"},{"key":"bibr98-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1038\/srep28106"},{"key":"bibr99-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119567"},{"key":"bibr100-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c00100"},{"key":"bibr101-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.110145"},{"key":"bibr102-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1039\/b500319a"},{"key":"bibr103-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2014.02.049"},{"key":"bibr104-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1038\/srep36473"},{"key":"bibr105-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202002982"},{"key":"bibr106-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000227"},{"key":"bibr107-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2013.09.002"},{"key":"bibr108-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36516"},{"key":"bibr109-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.200800030"},{"key":"bibr110-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200800683"},{"key":"bibr111-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5b00483"},{"key":"bibr112-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201704325"},{"key":"bibr113-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM01186A"},{"key":"bibr114-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.06.025"},{"key":"bibr115-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau9183"},{"key":"bibr116-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200604718"},{"key":"bibr117-08853282211003850","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.10.269"}],"container-title":["Journal of Biomaterials Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282211003850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08853282211003850","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08853282211003850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:51:26Z","timestamp":1777492286000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08853282211003850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":117,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1177\/08853282211003850"],"URL":"https:\/\/doi.org\/10.1177\/08853282211003850","relation":{},"ISSN":["0885-3282","1530-8022"],"issn-type":[{"value":"0885-3282","type":"print"},{"value":"1530-8022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,14]]}}}