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Setting up a physical barrier directly between the injured site and surrounding tissues is an effective solution for preventing this adverse situation. This study investigated a chitosan electrospun membrane (CSEM) as a potent anti-adhesion barrier, which was prepared by a needleless technology called Nanospider. Scanning electron microscopy revealed that CSEM is a laminated nanofiber with good mechanical properties. The fiber is uniform with the diameter distributing in the range of 100\u2013120\u2009nm. The tensile strength can reach 27.45\u2009\u00b1\u20096.30\u2009MPa with a maximum elongation at break of 18.50\u2009\u00b1\u20091.44%, which makes it stick easily to damaged parts but not to be easily damaged by tissue friction. The growth of S. aureus on CSEM was 59.18% lower than the control at 10\u2009h, which indicates its better antibacterial property. In addition, CSEM has good coagulant and biocompatibility characteristics. It can perform hemostatic function within 10\u2009min and the L929 mouse fibroblast viability on it was 92.18%\u2009\u00b1\u20091.08% on the seventh day. In vivo experiments indicated that CSEM significantly prevented peritoneal adhesions within four\u2009weeks after surgery with wound surface coverage. These results indicate that CSEM is a promising anti-adhesion barrier material.<\/jats:p>","DOI":"10.1177\/08853282211008109","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T03:23:15Z","timestamp":1618197795000},"page":"321-331","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["A nano chitosan membrane barrier prepared via Nanospider technology with non-toxic solvent for peritoneal adhesions\u2019 prevention"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1952-1415","authenticated-orcid":false,"given":"Shuo","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyue","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Engineering, Virginia Commonwealth University, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Shanghai Qisheng Biological Preparation Co. 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