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Therefore, the present work was aimed to evaluate the effect of local administration with TUDCA on HA-coated titanium implants osseointegration in ovariectomized(OVX) rats and further investigation of the possible mechanism. Twelve weeks after bilateral ovariectomy, all animals were randomly divided into three groups: sham operation(Sham) group, OVX group and TUDCA group, and all the rats from Sham group and OVX group received HA implants and animals belonging to group TUDCA received TUDCA-HA implants until death at 12\u2009weeks. The bilateral femurs of rats were harvested for evaluation. TUDCA increased new bone formation around the surface of titanium rods and push-out force other than group OVX. Histology, Micro-CT and biochemical analysis results showed systemic TUDCA showed positive effects than OVX group on bone formation in osteopenic rats, with beneficial effect on via activation OPG\/RANKL pathway and BMP-2\/Smad1 pathway and microarchitecture as well as by reducing protein expression of TNF-\u03b1 and IFN-\u03b3. The present study suggests that local use of TUDCA may bring benefits to the osseointegration of HA-coated titanium implants in patients with osteoporosis, and this effect may be related to the inhibition of inflammatory reaction and promotion of osteogenesis.<\/jats:p>","DOI":"10.1177\/08853282211027678","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T02:34:30Z","timestamp":1624502070000},"page":"552-561","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Local administration with tauroursodeoxycholic acid could improve osseointegration of hydroxyapatite-coated titanium implants in ovariectomized rats"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-9289","authenticated-orcid":false,"given":"Zhou-Shan","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Trauma Orthopedics, The First Affiliated Hospital of 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