{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:10:36Z","timestamp":1785813036587,"version":"3.56.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ministry of Science and Technology of the Republic of China","award":["MOST 108-2218-E-011-017-MY3"],"award-info":[{"award-number":["MOST 108-2218-E-011-017-MY3"]}]},{"name":"Ministry of Science and Technology of the Republic of China","award":["MOST 109-2113-M-011-001"],"award-info":[{"award-number":["MOST 109-2113-M-011-001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>\n                    In this work, manganese (Mn)-doped CuInSe quantum dots (QDs) with a ZnS passivation layer (MnCuInSe\/ZnS) have been synthesized via a one-pot microwave-assisted hydrothermal reaction using glutathione (GSH) as a stabilizer. The MnCuInSe\/ZnS core-shell QDs combine magnetic resonance imaging (MRI), excitation-dependent red emission, and reactive oxygen radical generation functions, in which regulation of Mn\n                    <jats:sup>2+<\/jats:sup>\n                    incorporation leads to synergistic imaging and therapeutic modalities. The MnCuInSe\/ZnS QDs exhibit high colloidal and photochemical stability in simulated media and at different pH values. An r\n                    <jats:sub>2<\/jats:sub>\n                    \/r\n                    <jats:sub>1<\/jats:sub>\n                    ratio of 9.99 was calculated from MRI studies suggesting their potential application as dual-modal imaging agents. Based on in vitro tests on Hela, B16, and HepG2 cell lines, it is apparent that MnCuInSe\/ZnS QDs impose no significant cytotoxicity in the dark, while they can efficiently generate singlet oxygen radicals for photodynamic therapy of cancers, killing more than 80% of B16 cells within 5\u00a0min of laser irradiation (671\u00a0nm, 1\u00a0W cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ). Furthermore, in vitro fluorescence imaging and cellular internalization of QDs are examined to visualize cellular uptake and in situ ROS generation. Therefore, this research exemplifies a new set of multifunctional chalcogenide QDs for theranostic applications.\n                  <\/jats:p>","DOI":"10.1177\/08853282211068959","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T04:36:01Z","timestamp":1645418161000},"page":"1617-1628","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Multifunctional MnCuInSe\/ZnS quantum dots for bioimaging and photodynamic therapy"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-9330","authenticated-orcid":false,"given":"Novi","family":"Irmania","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalilalrahman","family":"Dehvari","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yaw","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, 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