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Although the combination of an inorganic and organic phase resulted in a decrease of the compressive strength from about 10\u00a0MPa without polymeric phase to 3\u20136\u2013MPa for gelatin modified composites, an increase in elastic properties due to the gelatin hydrogel with a concentration of 10.0\u00a0w\/v% was achieved. For a powder-to-liquid ratio of 2.5\u00a0g*mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , a shift of initial maximum stress value during compression testing was observed up to 5% deformation and tested samples showed a pseudo-ductile fracture behavior. The obtained composites of the different formulations were characterized regarding phase composition, porosity as well as drug loading capacity with rifampicin and vancomycin. For the latter, a sustained and prolonged release was realized with a drug release profile according to the Higuchi model and a release exponent of n = 0.5 for the formulation with a PLR of 2.5\u00a0g*mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    and an incorporation of 10.0\u00a0w\/v% gelatin.\n                  <\/jats:p>","DOI":"10.1177\/08853282221075877","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T03:46:50Z","timestamp":1647143210000},"page":"1882-1898","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Dual setting brushite\u2014gelatin cement with increased ductility and sustained drug release"],"prefix":"10.1177","volume":"36","author":[{"given":"Michaela","family":"R\u00f6del","sequence":"first","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Te\u00dfmar","sequence":"additional","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Groll","sequence":"additional","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2584-4176","authenticated-orcid":false,"given":"Uwe","family":"Gbureck","sequence":"additional","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,12]]},"reference":[{"key":"bibr1-08853282221075877","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2013.01.001"},{"key":"bibr2-08853282221075877","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(89)90089-6"},{"key":"bibr3-08853282221075877","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.01.004"},{"key":"bibr4-08853282221075877","doi-asserted-by":"publisher","DOI":"10.1039\/C2TB00153E"},{"key":"bibr5-08853282221075877","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.04.015"},{"key":"bibr6-08853282221075877","first-page":"61","volume":"27","author":"Desai TR","year":"2007","journal-title":"Ceram Eng Sci Proc (Am Ceram Soc)"},{"key":"bibr7-08853282221075877","volume-title":"Of Monetite (CaHPO4)-Based Orthopedic and Dental Cements of High Resorbability","author":"Development T.R. 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