{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:53:05Z","timestamp":1783720385733,"version":"3.55.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ortho Regenerative Technologies Inc"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>Freeze-dried formulations of chitosan can be solubilized in platelet-rich plasma (PRP) to form injectable implants that are used as an adjunct treatment during surgical repair of the rotator cuff. The purpose of the current study was to assess chitosan-PRP implant residency, test safety, and assess efficacy over standard-of-care controls in a sheep model of rotator cuff repair. The infraspinatus tendon was transected unilaterally and immediately repaired with suture anchors in 22 skeletally mature ewes. In treatment groups, formulations containing chitosan, trehalose, and calcium chloride were solubilized with autologous leukocyte-rich PRP and injected at the tendon-bone interface and on top of the repaired site (1\u00a0mL or 2\u00a0mL doses). Implant residency was assessed histologically at 1 day. Outcome measures included MRI assessment at baseline, 6\u00a0weeks, and 12\u00a0weeks, histopathology and clinical pathology. Chitosan-PRP implants were resident at the injection site at 1 day and induced recruitment of polymorphonuclear cells. The tendon gap, which corresponds to the length of abnormally hyperintense tissue attached to the humeral head, was decreased by treatment with the 2\u00a0mL dose when compared to controls at 12\u00a0weeks on MRI images. Some histological features were improved by the 2\u00a0mL dose treatment compared to controls at 12\u00a0weeks. There was no treatment-specific effect on all standard safety outcome measures, which suggests high safety. This study provides preliminary evidence on the safety and efficacy of chitosan-PRP implants in a large animal model that could potentially be translated to a clinical setting.<\/jats:p>","DOI":"10.1177\/08853282221085058","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T05:26:43Z","timestamp":1650259603000},"page":"183-194","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Chitosan-platelet-rich plasma implants improve rotator cuff repair in a large animal model: Pilot study"],"prefix":"10.1177","volume":"37","author":[{"given":"Anik","family":"Chevrier","sequence":"first","affiliation":[{"name":"Polytechnique Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B","family":"Hurtig","sequence":"additional","affiliation":[{"name":"University of Guelph"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2750-3607","authenticated-orcid":false,"given":"Marc","family":"Lavertu","sequence":"additional","affiliation":[{"name":"Polytechnique Montreal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2013.01.008"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2009.04.006"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512462677"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546514525336"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.01173"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512453300"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-013-1914-3"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-014-2026-4"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2011.08.265"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546515587081"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2016.01.036"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516645518"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546518795895"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512442924"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546511424402"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.20.3.569"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4880-1_14"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.2403"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/aa8469"},{"key":"e_1_3_3_21_2","first-page":"792","article-title":"Freeze-dried chitosan-platelet-rich plasma implants improve supraspinatus tendon attachment in a transosseous rotator cuff repair model in the rabbit","volume":"33","author":"Depr\u00e9s-Tremblay G","year":"2019","unstructured":"Depr\u00e9s-Tremblay G, Chevrier A, Snow M, et al. 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