{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:56:50Z","timestamp":1777787810807,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Rehabilitation Research & Development Award by the Department of Veterans Affairs","award":["RX001818-01"],"award-info":[{"award-number":["RX001818-01"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Prosthesis with antibiotic-eluting nanofibrous (NF) coating represents coating alternative to prevent periprosthetic joint infection (PJI). In this study, four formulas of erythromycin (EM)-embedded both in core and sheath components of coaxial PCL\/PLGA-PVA NF coatings were developed: EM 0 (no EM), EM 100 (100\u00a0\u03bcg\/mL), EM500 (500\u00a0\u03bcg\/mL) and EM1000 (1000\u00a0\u03bcg\/mL). EM doping altered the physicochemical and structural properties of NFs to some extent, including the increase of NF porosity and surface wettability. A sustained EM release from EM-NFs for &gt;4 weeks was observed. Eluents collected from EM-NFs showed strong zone of inhibition (ZOI) to Staphylococcus aureus growth and the sizes of ZOI positively related to the amount of EM released. EM-NFs were nontoxic to rat bone marrow stem cells (rBMSCs). Cell growth was significantly enhanced when comparing rBMSCs cultured on EM-NFs (EM0 and EM 100) to those cultured on NF-free control. Cell differentiation (ALP activity) was notably enhanced by EM100, compared to control and EM0. Eluents from EM-NFs on rBMSCs were also investigated. The presence of 10% EM-NF eluents inhibited the growth of rBMSCs, which was proportional to the amount of EM doped. The ALP activity was notably enhanced by eluents from EM-NFs with the highest activity in EM100 compared to control and EM0. Our data indicate that EM-doped PCL\/PLGA-PVA coaxial NF coatings have a great potential to be applied as a new implant coating matrices. Further in vivo testing in animal models is currently planned that should represent the first step in predicting the clinical outcomes of EM-eluting NF coating approach.<\/jats:p>","DOI":"10.1177\/08853282221105676","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T23:04:31Z","timestamp":1653692671000},"page":"712-723","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Osteoblastic differentiation and bactericidal activity are enhanced by erythromycin released from PCL\/PLGA-PVA coaxial nanofibers"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-5551","authenticated-orcid":false,"given":"Weiping","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Orthopedic, Ascension Providence Hospital, Southfield, MI, USA"},{"name":"John D Dingle VA Medical Center, Detroit, MI, USA"},{"name":"Biomedical Engineering, Wayne 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