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After addition 0 \u223c 25% \u03b1-CSH to the \u03b1-TCP cement with SFFs as curing liquid, it shortened the setting time of the modified composite to 10 \u223c 30\u00a0min. Furthermore, the addition of SFFs improved the compressive strength of the composite from 5.41\u00a0MPa to 9.44\u00a0MPa. The composites with both Na\n                    <jats:sub>2<\/jats:sub>\n                    HPO\n                    <jats:sub>4<\/jats:sub>\n                    and SFFs as curing liquid showed good anti-collapse performance. The weight loss ratio of bone cement was \u22120.18 \u223c 12.08% in 4\u00a0weeks when the content of \u03b1-CSH in \u03b1-TCP\/\u03b1-CSH was between 0 \u223c 25\u00a0wt%. During the degradation of \u03b1-CSH, the amorphous \u03b1-TCP were deposited as hydroxyapatite to formed a plate-like products on the surface of composite. Compared to the composite with Na\n                    <jats:sub>2<\/jats:sub>\n                    HPO\n                    <jats:sub>4<\/jats:sub>\n                    solution as the curing liquid, alkaline phosphatase (ALP) activity of the composites using SFFs as curing liquid were maintained at high levels on the 14th day especially when the Ca\/P ratio was 1.7. This study provides a theoretical basis for the regeneration of bone defects guided by bone cement materials.\n                  <\/jats:p>","DOI":"10.1177\/08853282231172855","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T20:02:48Z","timestamp":1682452968000},"page":"1801-1812","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The study of self-regulating \u03b1-TCP based composite by micro\/nano scaled silk fibroin and \u03b1-CSH on physicochemical and biological properties of bone cement"],"prefix":"10.1177","volume":"37","author":[{"given":"Yaping","family":"Song","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Research Center for Nano-Biomaterials and Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 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