{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T05:59:28Z","timestamp":1777787968412,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The 2017 Harbin application technology and development project","award":["No. 2017RAQXJ090"],"award-info":[{"award-number":["No. 2017RAQXJ090"]}]},{"name":"The Science and Technology Research Project of Heilongjiang Provincial Education Department","award":["No. 12531624"],"award-info":[{"award-number":["No. 12531624"]}]},{"DOI":"10.13039\/501100005046","name":"Heilongjiang Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["No. H2016076"],"award-info":[{"award-number":["No. H2016076"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005046","name":"The Heilongjiang Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["No. LH2022H085"],"award-info":[{"award-number":["No. LH2022H085"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Heilongjiang Traditional Chinese Medicine Research Project","award":["ZHY2022-111"],"award-info":[{"award-number":["ZHY2022-111"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Biomater Appl"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>This study aimed to create a glycyrrhetinic acid (GA)-mediated, multi-component, self-assembled nano-drug delivery system co-loaded with syringopicroside (S) and hydroxytyrosol (H) obtained from Syringa Linn by synthesizing a GA-polyethylene glycol-poly (lactic acid-co-glycolic acid) (GPP) nanoparticle delivery carrier to actively target the liver. The nanoparticles were optimized using the central composite design. Nanoparticle characterization, cytotoxicity, pharmacodynamics, and tissue distribution study were performed. The optimized SH-GPP nanoparticle was a white solid powder, which was safe and non-toxic. The particle size and Zeta potential of the nanoparticles were 101.5 \u00b1 3.18\u00a0nm and \u221223.3 \u00b1 0.82\u00a0mV, respectively. The polydispersity index value (PDI) was 0.190 \u00b1 0.005; the particle size distribution was comparatively uniform. The average total encapsulation efficiency of the optimized SH-GPP nanoparticle was 50.26% \u00b1 1.29%, and drug loading was 15.47% \u00b1 0.39%. After S and H were arranged into nanoparticles, the proliferation inhibition of HepG2.2.15 cells was improved, and the aim of drug-loaded synergism between GPP and SH was achieved. The GA-mediated nanoparticles were better targeted, were retained longer in vivo, and had higher concentrations in the liver than the unmodified nanoparticles. These nanoparticles have the potential to be a new effective anti-hepatitis B treatment and have great research potential in clinical treatment.<\/jats:p>","DOI":"10.1177\/08853282231188460","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:24:20Z","timestamp":1692984260000},"page":"392-411","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Preparation, characterization, and\n                    <i>in vivo<\/i>\n                    evaluation of glycyrrhetinic acid-mediated nano-drug delivery system co-loaded with syringopicroside and hydroxytyrosol"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-9154","authenticated-orcid":false,"given":"QingXia","family":"Guan","sequence":"first","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, Heilongjiang Vocational College for Nationalities, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoYing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiuYan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"bibr1-08853282231188460","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-19"},{"issue":"9","key":"bibr2-08853282231188460","first-page":"813","volume":"31","author":"Zhang G","year":"2021","journal-title":"Chinese Journal of Intergrated Tarditional and Western Medicine on Liver Diseaes"},{"issue":"21","key":"bibr3-08853282231188460","first-page":"206","volume":"19","author":"Li T","year":"2021","journal-title":"Chinese Medicine Modern Distance Education of China"},{"issue":"11","key":"bibr4-08853282231188460","first-page":"23","volume":"48","author":"Zhang X","year":"2020","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"bibr5-08853282231188460","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26051295"},{"issue":"2","key":"bibr6-08853282231188460","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/0920203X110250010502","volume":"28","author":"Zhang X","year":"2011","journal-title":"Information of Chinese Medicine"},{"key":"bibr7-08853282231188460","first-page":"468","volume":"4","author":"Gao S","year":"2003","journal-title":"Journal of Jilin University (Medical Edition)"},{"issue":"12","key":"bibr8-08853282231188460","first-page":"12","volume":"14","author":"Jiang Y","year":"2016","journal-title":"Chinese Journal of Community Medicine"},{"issue":"08","key":"bibr9-08853282231188460","first-page":"1381","volume":"22","author":"Zhang X","year":"2019","journal-title":"Chinese Pharmacist"},{"key":"bibr10-08853282231188460","unstructured":"Zang H, Zhang L, Qian X, et al. 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